[1]李海东,方伟,吴素兰,等.非增生期糖尿病视网膜病变患者黄斑区血流密度变化：基于OCTA的定量分析[J].眼科新进展,2021,41(2):170-173.[doi:10.13389/j.cnki.rao.2021.0036]
　LI Haidong,FANG Wei,WU Sulan,et al.Quantitative analysis of macular vessel density changes in non-proliferative diabetic retinopathy through optical coherence tomography angiography[J].Recent Advances in Ophthalmology,2021,41(2):170-173.[doi:10.13389/j.cnki.rao.2021.0036]
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非增生期糖尿病视网膜病变患者黄斑区血流密度变化：基于OCTA的定量分析/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
41卷
期数:
2021年2期
页码:
170-173
栏目:
应用研究
出版日期:
2021-02-05

文章信息/Info

Title:
Quantitative analysis of macular vessel density changes in non-proliferative diabetic retinopathy through optical coherence tomography angiography
作者:
李海东; 方伟; 吴素兰; 廉恒丽; 徐小琼; 董思思; 沈丽君
310020　浙江省杭州市，温州医科大学附属眼视光医院杭州院区
Author(s):
LI Haidong; FANG Wei; WU Sulan; LIAN Hengli; XU Xiaoqiong; DONG Sisi; SHEN Lijun
Hangzhou Branch of Eye Hospital,Wenzhou Medical University,Hangzhou 310020,Zhejiang Province,China
关键词:
糖尿病视网膜病变; 黄斑; 血流密度; 光学相干断层扫描血管成像
Keywords:
diabetic retinopathy;  macula;  vessel density;  optic coherence tomography angiography
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2021.0036
文献标志码:
A
摘要:
目的　应用光学相干断层扫描血管成像（OCTA）定量分析非增生期糖尿病视网膜病变（NPDR）患者黄斑区视网膜血流密度（retinal vessel density，RVD）的改变。方法　回顾性横断面观察性研究。纳入2019年1月至12月在温州医科大学附属眼视光医院杭州院区就诊的2型糖尿病且伴NPDR的患者28例45眼（NPDR组），以及同期年龄、性别与之匹配的正常体检者20人40眼（正常对照组）。所有受检眼均采用分频幅去相关血流成像算法OCTA检查，扫描以黄斑中心凹为中心的3 mm×3 mm范围视网膜，自动获取黄斑旁中心凹区（中心1~3 mm）浅层和深层RVD并进行比较。结果　NPDR组黄斑旁中心凹区RVD平均值与正常对照组相比，浅层下降6.47%［（43.54±4.43）%、（46.55±4.13）%］，深层下降6.06%［（45.62±5.87）%、（48.56±5.31）%］，差异均有统计学意义（均为P＜0.05）。NPDR组浅层RVD各象限平均值均低于正常对照组，差异均有统计学意义［颞侧(42.34±4.40)%、(46.06±3.85)%，上方(44.33±5.57)%、(47.92±4.26)%，鼻侧(42.96±4.50)%、(45.50±4.31）%，下方（44.58±4.45）%、（46.88±4.94）%，均为P＜0.05］，其中颞侧RVD下降幅度最大（8.07%）。NPDR组深层RVD各象限平均值均低于正常对照组，除上方象限差异无统计学意义外［（45.43±6.30)%、(47.82±5.54)%，P=0.068］，其他象限差异均有统计学意义［颞侧（45.84±5.71）%、（49.54±4.86）%，鼻侧（46.53±5.91）%、（49.45±5.29）%，下方（44.62±6.64）%、（47.43±5.91）%，均为P＜0.05］，其中颞侧RVD下降幅度最大（7.48%）。结论　NPDR患者存在黄斑区浅层和深层视网膜毛细血管损害，颞侧尤甚。
Abstract:
Objective　To investigate quantitative changes of macular retinal vessel density (RVD) in non-proliferative diabetic retinopathy (NPDR) through optical coherence tomography angiography (OCTA). Methods　A retrospective cross-sectional observational study. From January to December 2019, twenty-eight patients (45 eyes) with NPDR from Type 2 diabetes mellitus (NPDR group) and 20 individuals (40 eyes) of age and sex matched healthy subjects (control group) in Hangzhou Branch of Eye Hospital of Wenzhou Medical University were included in the study. Automated OCTA/split-spectrum amplitude decorrelation angiography was applied in all eyes. A 3 mm×3 mm scan centered on the fovea was obtained, and the RVDs of superficial and deep retinal plexuses in parafoveal (central 1-3 mm) zone were analyzed.Results　Compared with the control group, the average parafoveal superficial and deep RVD of NPDR group decreased by 6.47% ［(43.54±4.43)%,(46.55±4.13)%］ and 6.06% ［(45.62±5.87)%,(48.56±5.31)%］ respectively, and both differences were statistically significant (all P<0.05). The superficial RVDs in all quadrants of the NPDR group were lower than those of the normal control group ［temporal (42.34±4.40)%, (46.06±3.85)%, superior (44.33±5.57)%, (47.92±4.26)%, nasal (42.96±4.50)%, (45.50±4.31)%, inferior (44.58±4.45)%, (46.88±4.94)%, respectively, all P＜0.05)］. Furthermore, the temporal quadrant had the largest vessel density reduction (8.07%). Similarly, the deep RVDs of all quadrants of the NPDR group were lower than their counterparts, and except that the difference in the superior quadrant was not statistically significant ［(45.43±6.30)%, (47.82±5.54)%, P=0.068］, the difference in the other quadrants was statistically significant ［temporal (45.84±5.71)%, (49.54±4.86)%, nasal (46.53±5.91)%, (49.45±5.29)%, inferior (44.62±6.64)%, (47.43±5.91)%, respectively, all P＜0.05］. The temporal area also had the largest vessel density reduction (7.48%).Conclusion　The macular superficial and deep retinal capillary layers are damaged in the patients with NPDR, especially in the temporal part.

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备注/Memo

备注/Memo:
N/A
更新日期/Last Update: 2021-02-05