DAI He-Hua,LI Gen-Lin.Research progress on ophthalmic delivery of glial cell line-derived neurotrophic factor’s intervention in retinitis pigmentosa[J].Recent Advances in Ophthalmology,2019,39(4):385-388.[doi:10.13389/j.cnki.rao.2019.0088]





Research progress on ophthalmic delivery of glial cell line-derived neurotrophic factor’s intervention in retinitis pigmentosa
100730 北京市,首都医科大学附属北京同仁医院,北京同仁眼科中心,北京市眼科学与视觉科学重点实验室
DAI He-HuaLI Gen-Lin
Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology & Visual Sciences Key Laboratory,Beijing 100730,China
retinitis pigmentosaglial cell line-derived neurotrophic factorophthalmic delivery
视网膜色素变性(retinitis pigmentosa,RP)的治疗目前仍处于探索阶段。胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)是目前研究中重要的神经营养因子,但其传统给药方式生物利用度相对较低。近年来GDNF安全有效的给药方式成为研究热点,包括经病毒载体或非病毒载体的基因工程法释药技术、经聚合物释放系统释药技术、经细胞移植释药技术、小分子触发器诱导产生GDNF等。本文就GDNF干预RP的给药方式进行综述。
Treatment for retinitis pigmentosa(RP)is still in an exploratory period at present.Glial cell line-derived neurotrophic factor(GDNF)is an important neurotrophic factor,but the conventional ophthalmic delivery of GDNF results in a very low bioavailability,so the safe and effective delivery of GDNF has become the hotspot in recent years,including viral or non-viral mediated gene therapy,polymer-release systems,cell transplantation and small molecules to induce GDNF.This article gives a brief overview on related research progress of new ophthalmic delivery of GDNF intervention in RP.


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更新日期/Last Update: 2019-04-15