[1]刘文凤,朱佩文,邵毅.线粒体功能障碍与角膜疾病研究进展[J].眼科新进展,2019,39(2):197-200.[doi:10.13389/j.cnki.rao.2019.0045]
 LIU Wen-Feng,ZHU Pei-Wen,SHAO Yi.Recent advance of mitochondrial dysfunction and corneal diseases[J].Recent Advances in Ophthalmology,2019,39(2):197-200.[doi:10.13389/j.cnki.rao.2019.0045]
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线粒体功能障碍与角膜疾病研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
39卷
期数:
2019年2期
页码:
197-200
栏目:
文献综述
出版日期:
2019-02-05

文章信息/Info

Title:
Recent advance of mitochondrial dysfunction and corneal diseases
作者:
刘文凤朱佩文邵毅
330006 江西省南昌市,南昌大学第一附属医院眼科
Author(s):
LIU Wen-FengZHU Pei-WenSHAO Yi
Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China
关键词:
线粒体DNA突变线粒体功能障碍角膜疾病
Keywords:
mtDNA mutationmitochondrial dysfunctioncorneal disease
分类号:
R772.2
DOI:
10.13389/j.cnki.rao.2019.0045
文献标志码:
A
摘要:
角膜是眼光学系统的重要组成部分,角膜疾病则是引起眼部刺激、不适及视力下降的重要原因。越来越多的研究表明,某些角膜疾病与线粒体功能障碍有关。正常角膜自身具有一套氧化与抗氧化应激系统。先天或后天长时间暴露于外界紫外线和高氧环境等原因,角膜内的氧化与抗氧化应激水平失衡,线粒体DNA突变并逐渐积累,最终角膜细胞能量产生障碍引起临床疾病。本文就线粒体功能障碍与某些遗传角膜疾病以及后天性角膜疾病的关系进行总结,旨在阐明氧化应激和粒体功能障碍在角膜疾病中作用,指导相关疾病靶向治疗药物的开发和应用。
Abstract:
Cornea is an important part of the optical system of the eye,and corneal disease is a vital cause of eye irritation,discomfort,and loss of vision.More and more studies have shown that corneal diseases are related to mitochondrial dysfunction.Normally,the cornea itself has a system of oxidative and antioxidant stress.Due to long-time exposure to ultraviolet rays and hyperoxia,the level of oxidative and antioxidative stress in cornea is unbalanced.The mitochondrial DNA (mtDNA) mutated and accumulated gradually,leading to corneal energy dysfunction and related clinical diseases.This review makes a summary on the relationship between mitochondrial dysfunction and inherited and acquired corneal diseases,and we hope to deepen the understanding the role of oxidative stress and mitochondrial dysfunction in corneal diseases and provide guidance for the development and application of targeted drugs for related diseases.

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备注/Memo

备注/Memo:
国家自然科学基金资助(编号:81660158、81460092、81400372);江西省自然科学基金重大项目(编号:2016ACB21017);江西省青年科学基金(编号:20151BAB215016、20161BAB215198);江西省重点研发项目(编号:20151BBG70223、20181BBG70004);江西省教育厅重点项目(编号:GJJ160020);江西省学位与研究生教育教学改革研究项目(编号:JXYJG-2018-013);江西省基层卫生适宜技术“星火推广计划”项目(编号:20088003);江西省卫计委科技计划面上项目(编号:20175116);江西省卫计委中医药科技计划项目(编号:20150823)
更新日期/Last Update: 2019-02-18