[1]许海蒙,张春巍.应用三维光学相干断层扫描仪对原发性开角型青光眼和正常眼脉络膜厚度的对比分析[J].眼科新进展,2018,38(6):560-562.[doi:10.13389/j.cnki.rao.2018.0131]
　XU Hai-Meng,ZHANG Chun-Wei.Assessment of choroidal thickness in healthy and primary open-angle glaucoma eyes using deep-range imaging optical coherence tomography[J].Recent Advances in Ophthalmology,2018,38(6):560-562.[doi:10.13389/j.cnki.rao.2018.0131]
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应用三维光学相干断层扫描仪对原发性开角型青光眼和正常眼脉络膜厚度的对比分析/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
38卷
期数:
2018年6期
页码:
560-562
栏目:
应用研究
出版日期:
2018-06-05

文章信息/Info

Title:
Assessment of choroidal thickness in healthy and primary open-angle glaucoma eyes using deep-range imaging optical coherence tomography
作者:
许海蒙; 张春巍
150001　黑龙江省哈尔滨市，哈尔滨医科大学附属第一医院眼科
Author(s):
XU Hai-Meng; ZHANG Chun-Wei
Ophthalmology，the First Affiliated Hospital of Harbin Medical University，Harbin 150001，Heilongjiang Province，China
关键词:
脉络膜厚度; 原发性开角型青光眼; 光学相干断层扫描
Keywords:
choroidal thickness;  primary open-angle glaucoma; optical coherence tomography
分类号:
R775.2
DOI:
10.13389/j.cnki.rao.2018.0131
文献标志码:
A
摘要:
目的　通过三维光学相干断层扫描仪比较原发性开角型青光眼（primary open-angle glaucoma，POAG）和正常眼的脉络膜厚度，并分析其影响因素，探讨脉络膜厚度与青光眼的关系。方法　选取140例（216眼）POAG患者作为青光眼组，67例（106眼）正常受试者作为正常组。采用日本Topcon公司生产的超景深广角眼底断层扫描仪对各组受试者脉络膜厚度进行检测。通过单变量和多变量回归分析受试者年龄、眼轴长度、角膜厚度、收缩压、舒张压、收缩期灌注压、舒张期灌注压、眼压以及视野缺损值等因素与脉络膜厚度的关系。结果　青光眼组受试者年龄、眼轴长度、收缩压、收缩期灌注压均高于正常组（均为P<0.05）；青光眼组受试者视野损害更严重，视野缺损值差异有统计学意义（P<0.001）；两组受试者角膜厚度、舒张压、眼压、舒张期灌注压差异均无统计学意义（均为P>0.05）；青光眼组受试者脉络膜厚度为（157.70±48.54）μm，正常组为（179.90±36.10）μm，差异有统计学意义（P<0.001）。对所有受试者脉络膜厚度与各因素进行单变量回归分析，结果提示脉络膜厚度与年龄、眼轴长度、是否青光眼均呈显著负相关（均为P<0.05）。在考虑年龄和眼轴长度等因素在内的多变量回归分析结果显示，当年龄和眼轴长度被矫正时，青光眼组与正常组之间的脉络膜厚度差异无统计学意义（P=0.216），是否青光眼与脉络膜厚度之间无相关性。结论　脉络膜厚度与青光眼无明显相关性，年龄、眼轴长度与脉络膜厚度呈负相关，脉络膜厚度不能作为诊断POAG和病情评估的指标。
Abstract:
Objective　To evaluate choroidal thickness（CT） in healthy and primary open-angle glaucoma （POAG） eyes using deep-range imaging optical coherence tomography （DRI -OCT） and to analyze the relationship between choroidal thickness and glaucoma.Methods　Totally 140 patients （216 eyes） with POAG were selected as glaucoma group，and 67 patients （106 eyes） with normal eyes as normal group.The optical coherence tomography produced by Japanese company （Topcon） was used to detect CT in both groups.The association between CT and potential confounding variables including age，axial length，central corneal thickness，systolic pressure，diastolic pressure，systolic perfusion pressure，diastolic perfusion pressure，intraocular pressure，and visual field defects were examined by using univariable and multivariable regression analyses.Results　The age，axial length，systolic blood pressure and systolic blood pressure of the glaucoma group were all higher than those of the normal group （ all P<0.05），and the subjects in the glaucoma group had more severe visual field damage，and the difference of visual field defect was statistically significant （P<0.001）.There was no significant difference in corneal thickness，diastolic blood pressure，intraocular pressure and diastolic perfusion pressure between the two groups （all P>0.05）.The CT was （157.70±48.54）μm in the glaucoma group，and （179.9±36.1）μm in the normal group，respectively，and the difference was statistically significant （P<0.001）.Uninitiated regression analysis showed that CT was negatively correlated with age，axial length and glaucoma （all P<0.05）.Multivariate regression analysis showed that there was no significant difference in CT between glaucoma group and normal group when the length of the age and the axis of the eye were corrected （P=0.216），and moreover，there was also no association between glaucoma severity and CT.Conclusion　Glaucoma is not associated with CT measured using DRI-OCT； however，older age and longer axial length were associated with thinner CT，so CT cannot be used as a marker for diagnosing POAG and assessing the condition of the disease.

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备注/Memo

备注/Memo:
黑龙江省留学归国科学基金项目（编号：LC2012C21）；黑龙江省教育厅科学技术研究项目（编号：12511311）；哈尔滨市科技创新人才研究专项基金项目（编号：2011RFLYS029）
更新日期/Last Update: 2018-07-10