[1]张悦,董宁.糖尿病视网膜病变中视网膜小胶质细胞活化及干预机制研究进展[J].眼科新进展,2017,37(9):890-893.[doi:10.13389/j.cnki.rao.2017.0226]
　ZHANG Yue,DONG Ning.Recent advances in microglia activation and intervention mechanism in diabetic retinopathy[J].Recent Advances in Ophthalmology,2017,37(9):890-893.[doi:10.13389/j.cnki.rao.2017.0226]
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糖尿病视网膜病变中视网膜小胶质细胞活化及干预机制研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年9期
页码:
890-893
栏目:
文献综述
出版日期:
2017-09-05

文章信息/Info

Title:
Recent advances in microglia activation and intervention mechanism in diabetic retinopathy
作者:
张悦; 董宁
300020　天津市，天津市眼科医院 天津医科大学眼科临床学院 天津市眼科研究所 天津市眼科学与视觉科学重点实验室
Author(s):
ZHANG Yue; DONG Ning
Tianjin Eye Hospital，Tianjin Key Laboratory of Ophthalmology and Vision Science，Clinical College of Ophthalmology，Tianjin Medical University，Tianjin 300020，China
关键词:
糖尿病视网膜病变; 小胶质细胞; 活化; 干预
Keywords:
diabetic retinopathy; microglia; activation; intervention
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2017.0226
文献标志码:
A
摘要:
糖尿病视网膜病变（diabetic retinopathy，DR）是糖尿病（diabetes mellitus，DM）最常见的并发症，其发病率随DM病程的延长而增高。DR是一种高发病率和高致盲率的疾病，对DR的发病机制研究一直是国内外的热点之一。但是DR的发病机制尚未完全阐明，近年来，越来越多的学者认为DR可能是一种慢性、低度炎性反应。小胶质细胞（microglia，MG）是视网膜中的单核巨噬细胞，具有抗原呈递功能，DR中MG被活化，释放大量炎症因子，参与DR的炎症反应。了解DR中MG的活化机制，可更好地为DR的预防和治疗开辟新的视角。因此，本文就DR中视网膜MG活化及干预机制进行综述。
Abstract:
Diabetic retinopathy （DR） is one of the most significant microvascular complications of diabetes，and its incidence increases with the prolongation of DM；meanwhile，it can lead to severe vision loss.Recently，the pathogenesis of DR has been one of the focuses both at home and abroad，but the basic mechanisms are not fully elucidated.More and more scholars believe that DR may be a chronic and low degree of inflammatory response.Moreover，it is well established that microglia is a monocyte-macrophage，with antigen-presenting function.Especially in the retina，as microglia is activated，followed by the release of a large number of inflammatory factors，microglia involves in DR inflammatory response.Understanding the activation mechanism of microglia can provide a new perspective for the prevention and treatment of DR.Therefore，recent advances in activation of microglia in diabetic retinopathy and its intervention mechanism will be reviewed in the article.

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备注/Memo

备注/Memo:
国家自然科学基金资助（编号：81400405）
更新日期/Last Update: 2017-10-12