[1]李妍,桑璇,王晓然,等.干眼患者泪膜脂质层厚度检测及其与眼表体征的相关性分析[J].眼科新进展,2017,37(4):344-347.[doi:10.13389/j.cnki.rao.2017.0087]
　LI Yan,SANG Xuan,WANG Xiao-Ran,et al.Measurement of tear film lipid layer thickness in dry eye patients and its relationship with ocular surface signs[J].Recent Advances in Ophthalmology,2017,37(4):344-347.[doi:10.13389/j.cnki.rao.2017.0087]
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干眼患者泪膜脂质层厚度检测及其与眼表体征的相关性分析/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年4期
页码:
344-347
栏目:
应用研究
出版日期:
2017-04-05

文章信息/Info

Title:
Measurement of tear film lipid layer thickness in dry eye patients and its relationship with ocular surface signs
作者:
李妍; 桑璇; 王晓然; 杨柳; 贺雄军; 王智崇; 陆晓和
510282　广东省广州市，南方医科大学珠江医院眼科(李妍，贺雄军，陆晓和)；510060　广东省广州市，中山大学中山眼科中心眼科学国家重点实验室(桑璇，王晓然，杨柳，王智崇)
Author(s):
LI Yan; SANG Xuan; WANG Xiao-Ran; YANG Liu; HE Xiong-Jun; WANG Zhi-Chong; LU Xiao-He
Department of Ophthalmology,Zhujiang Hospital of Southern Medical University(LI Yan,HE Xiong-Jun,LU Xiao-He),Guangzhou 510282,Guangdong Province,China;State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University (SANG Xuan,WANG Xiao-Ran,YANG Liu,WANG Zhi-Chong),Guangzhou 510060,Guangdong Province,China
关键词:
泪膜脂质层; 干眼; 睑板腺功能障碍; 眼表体征; 年龄
Keywords:
tear film lipid layer; dry eye; meibomian gland dysfunction; ocular surface signs; age
分类号:
R777.3
DOI:
10.13389/j.cnki.rao.2017.0087
文献标志码:
A
摘要:
目的　检测干眼患者泪膜脂质层厚度（lipid layer thickness，LLT），并分析LLT与眼表体征之间的相关性。方法　纳入130例（130眼）干眼患者为本研究研究对象，其中睑板腺功能障碍（meibomian gland dysfunction，MGD）患者64例，非MGD患者66例，进行LLT检测、泪膜破裂时间（break-up time，BUT）检查、角膜荧光素染色（fluorescein staining，FL）、Marx线（Marx line，ML）评分及SchirmerⅠ试验。分析不同年龄段LLT分布情况，及其与其他检查之间的相关性。结果　不同年龄段之间LLT差异有统计学意义（P=0.007），各年龄段男性与女性之间LLT差异均无统计学意义（均为P＞0.05）。LLT与年龄呈正相关（r=0.334，P＜0.001），LLT与性别无显著相关性（r=0.107，P=0.226）。LLT与上睑ML评分（r=0.295，P=0.001）、下睑ML评分（r=0.233，P=0.008）呈正相关，与BUT、FL及泪液分泌量均无显著相关性（均为P＞0.05）。MGD组LLT与上睑ML评分、下睑ML评分呈正相关（均为r=0.306，P=0.014），与其他检查指标均无显著相关性（均为P＞0.05）。非MGD组LLT与其他检查指标均无显著相关性（均为P＞0.05）。多元线性回归分析结果显示，干眼患者中，年龄、上睑ML评分与LLT存在线性关系（年龄：β=0.254，P=0.005；上睑ML评分：β=0.207，P=0.022），在MGD组中，仅年龄与LLT存在线性关系（β=0.382，P=0.002）。MGD组上睑ML评分及下睑ML评分均高于非MGD组（均为P＜0.001）。结论　干眼患者LLT与年龄、ML评分呈正相关。泪膜LLT检测作为干眼诊断的辅助检查时，需结合年龄等影响因素进行综合分析。
Abstract:
Objective　To measure the tear film lipid layer thickness (LLT) in dry eye patients and investigate the correlations of LLT with ocular surface signs.Methods　One hundred and thirty dry eye patients (130 eyes),including 64 meibomian gland dysfunction (MGD) patients and 66 non-MGD patients,were included in this study.LLT,break-up time (BUT),fluorescein staining (FL),Marx’s line (ML) score and SchirmerⅠtest were performed and examined.The distribution of LLT in different age groups and the correlations between LLT and other examinations were analyzed.Results　There was significant difference in LLT among different age groups (P=0.007),while LLT was not significantly different between male and female in each age group (P＞0.05).LLT was positively correlated with age (r=0.334，P＜0.001) and was not correlated with sex (r=0.107，P=0.226).LLT was positively correlated with upper eyelid ML score (r=0.295，P=0.001) and lower eyelid ML score (r=0.233，P=0.008).There was no significant correlation of LLT with BUT,FL or SchirmerⅠtest (all P>0.05).In the MGD group,there were positive correlations of LLT with upper eyelid ML score and lower eyelid ML score (all r=0.306,P=0.014),and no correlation of LLT with other examinations (all P>0.05).In the non-MGD group,there was no correlation of LLT with other examinations (all P>0.05).In a multivariate linear regression analysis,age and upper eyelid ML score were significantly related to LLT (β=0.254,P=0.005 for age and β=0.207,P=0.022 for upper eyelid ML score) in all dry eye patients.Age was the only factor related to LLT (β=0.382,P=0.002) in the MGD group.Upper eyelid ML score and lower eyelid ML score were higher in the MGD group than the non-MGD subgroup (all P＜0.001).Conclusion　LLT is positively correlated with age and ML score in dry eye patients.The measurement of tear film LLT,as an auxiliary examination in the diagnosis of dry eye disease,should be analyzed with the influential factors including age.

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备注/Memo

备注/Memo:
广东省前沿与关键技术创新专项资金（省重大科技专项）（编号：2015B020227001）；广州市科技计划科学研究专项（重点项目）（编号：15020083）；眼科学国家重点实验室专项经费（编号：2012PI05）；中山大学中山眼科中心“五个五培育项目”
更新日期/Last Update: 2017-04-26