[1]吴超琼,朱晶.缺铁性贫血和健康儿童视网膜神经纤维层厚度的对比分析[J].眼科新进展,2017,37(1):056-58.[doi:10.13389/j.cnki.rao.2017.0015]
　WU Chao-Qiong,ZHU Jing.Comparison of retinal nerve fiber layer thickness between iron deficiency anemia and healthy children[J].Recent Advances in Ophthalmology,2017,37(1):056-58.[doi:10.13389/j.cnki.rao.2017.0015]
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缺铁性贫血和健康儿童视网膜神经纤维层厚度的对比分析/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
37卷
期数:
2017年1期
页码:
056-58
栏目:
应用研究
出版日期:
2017-01-05

文章信息/Info

Title:
Comparison of retinal nerve fiber layer thickness between iron deficiency anemia and healthy children
作者:
吴超琼; 朱晶
430022　湖北省武汉市，武汉市第一医院
Author(s):
WU Chao-Qiong; ZHU Jing
Department of Ophthalmology，Wuhan No.1 Hospital，Wuhan 430022，Hubei Province，China
关键词:
缺铁性贫血; 视网膜神经纤维层; 血红蛋白
Keywords:
iron deficiency anemia; retinal nerve fiber layer; hemoglobin
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2017.0015
文献标志码:
A
摘要:
目的　对比分析缺铁性贫血(iron deficiency anemia，IDA)儿童和健康儿童的视网膜神经纤维层(retinal nerve fiber layer，RNFL)厚度。方法　选取IDA儿童58例116眼和健康儿童46例92眼，分别纳入IDA组和对照组。对所有儿童进行眼压、等效球镜度和血红蛋白浓度测定，并于同日进行光学相干断层扫描仪检测，以获得上方、下方、鼻侧、颞侧和平均RNFL厚度。IDA组儿童接受铁剂治疗后检测RNFL厚度和血红蛋白浓度的变化。使用SPSS 19.0对数据进行统计学分析。结果　与健康儿童相比，IDA儿童的RNFL厚度较薄。对于合并IDA的青光眼或视神经病变儿童，应综合进行贫血的内科治疗。IDA组儿童血红蛋白浓度显著低于对照组(t=-21.99，P=0.00)，分别为(69.59±5.78)g·L-1和(145.46±6.20)g·L-1。IDA组儿童上方、下方和平均RNFL厚度均低于对照组(均为P<0.05)，而鼻侧和颞侧RNFL厚度与对照组差异均无统计学意义(均为P>0.05)。对IDA儿童的平均RNFL厚度和同期血红蛋白浓度行Spearman相关分析，结果显示平均RNFL厚度与血红蛋白浓度呈正相关(r=0.725，P=0.03)。IDA组儿童接受规范的铁剂治疗后，血红蛋白浓度由(69.59±5.78)g·L-1上升到(132.47±6.24) g·L-1。此时所有儿童均接受OCT复查RNFL厚度。结果显示上方、下方、鼻侧、颞侧和平均RNFL厚度分别为(180.11±50.58)μm、(168.79±47.14)μm、(188.57±39.86)μm、(185.34±42.67)μm和(180.48±41.98)μm，铁剂治疗后上方RNFL厚度较治疗前有所增厚(t=-21.25，P=0.04)。结论　与健康儿童相比，IDA儿童的RNFL厚度较薄。对于合并IDA的青光眼或视神经病变儿童，应综合进行贫血的内科治疗。
Abstract:
Objective　To observe and compare the retinal nerve fiber layer (RNFL) thickness in iron deficiency anemia (IDA) and healthy children Methods　One hundred and sixteen eyes from 58 children with IDA,as well as 92 eyes from 46 healthy children were consecutively enrolled in IDA group and control group respectively.Intraocular pressure,spherical equivalent refraction,and hemoglobin concentration were routinely examined.On the same day,RNFL thickness (superior,inferior,nasal,temporal,and average) was measured using optical coherence tomography,and the information was recorded for statistical analysis using SPSS 19.0.Results　RNFL thickness of IDA children was thinner than that of healthy children.The hemoglobin concentration of IDA and healthy children were (69.59±5.78)g·L-1 and (145.46±6.20)g·L-1,there was a significant difference (t=-21.99,P=0.00).The upper,lower and average RNFL thickness of IDA children were all thinner than those of healthy children (all P<0.05),but there was no statistically significant difference in nasal and temporal RNFL thickness (all P>0.05).The average RNFL thickness was positive correlated with hemoglobin concentration (r=0.725,P=0.03).The hemoglobin concentration of IDA children after iron treatment was increased from (69.59±5.78)g·L-1 to (132.47±6.24)g·L-1,the upper,lower,nasal and temporal RNFL thickness were (180.11±50.58)μm,(168.79±47.14)μm,(188.57±39.86)μm and (180.48±41.98) μm,respectively,there was a significant difference compared with that before treatment (t=-21.25,P=0.04).Conclusion　Compared with the healthy children,RNFL thickness measured by OCT is thinner in children with IDA.For those children with IDA and concomitant glaucoma or optic neuropathy,the treatment of anemia should be paid attention.

参考文献/References:

［1］　POWERS JM，DANIEL CL，MCCAVIT TL，BUCHANAN GR.Deficiencies in the management of iron deficiency anemia during childhood［J］.Pediatr Blood Cancer，2016，63(4):743-745.
［2］　中国儿童铁缺乏症流行病学调查协作组.中国7个月~7岁儿童铁缺乏症流行病学的调查研究［J］.中华儿科杂志，2001，42(12):886-891.
Chinese Children Iron Deficiency Epidemiological Investigation Group.Prevalence of iron deficiency in children aged 7 months to 7 years in China［J］.Chin J Pediatr,2001,42(12):886-891.
［3］　吴玲玲，赵正言.铁缺乏对中枢神经系统髓鞘化的影响［J］.中国妇幼健康研究，2006，17(1):35-37.
WU LL,ZHAO ZY.Effect of iron deficiency on myelination in CNS［J］.Chin J Matern Child Health Res，2006,17(1):35-37.
［4］　GARCIA T，TOURBAH A，SETROUK .Optical coherence tomography in neuro- ophthalmology［J］.J Fr Ophtalmol，2012，35(6):454-466.
［5］　LIM HB，KIM MS，JO YJ，KIM JY.Prediction of retinal ischemia in branch retinal vein occlusion:spectral-domain optical coherence tomography study［J］.Invest Ophthalmol Vis Sci，2015，56(11):6622-6629.
［6］　CHEN X，NIE C，GONG Y，ZHANG Y，JIN X，WEI S.Peripapillary retinal nerve fiber layer changes in preclinical diabetic retinopathy:a meta-analysis［J］.PLoS One，2015，10(5):e0125919.
［7］　YU JG，MEI ZM，YE T，FENG YF，ZHAO F，JIA J，et al.Changes in retinal nerve fiber layer thickness in obstructive sleep apnea/hypopnea syndrome:A Meta-Analysis［J］.Ophthalmic Res，2016，56(2):57-67.
［8］　COPPOLA G，Di RENZO A，ZICCARDI L，MARTELLI F，FADDA A，MANNI G，et al.Optical coherence tomography in alzheimer’s disease:A meta-analysis［J］.PLoS One，2015，10(8):e0134750.
［9］　CHOW CC，SHAH RJ，LIM JI，CHAU FY，HALLAK JA，VAJARANANT TS.Peripapillary retinal nerve fiber layer thickness in sickle-cell hemoglobinopathies using spectral-domain optical coherence tomography［J］.Am J Ophthalmol，2013，155(3):456-464.
［10］　CIKMAZKARA I，UGURLU SK.Peripapillary retinal nerve fiber layer thickness in patients with iron deficiency anemia［J］.Indian J Ophthalmol，2016，64(3):201-205.
［11］　MILTO IV，SUHODOLO IV，PROKOPIEVA VD，KLIMENTEVA TK.Molecular and cellular bases of iron metabolism in humans［J］.Biochemistry (Mosc)，2016，81(6):549-564.
［12］　MOISEYEV G，TAKAHASHI Y，CHEN Y，GENTLEMAN S，REDMOND TM，CROUCH RK，et al.RPE65 is an iron(II)-dependent isomerhydrolase in the retinoid visual cycle［J］.J Biol Chem，2006，281(5):2835-2840.
［13］　ORTIZ E，PASQUINI JM，THOMPSON K，FELT B，BUTKUS G，BEARD J，et al.Effect of manipulation of iron storage，transport，or availability on myelin composition and brain iron content in three different animal models［J］.J Neurosci Res，2004，77(5):681-689.
［14］　TODORICH B，PASQUINI JM，GARCIA CI，PAEZ PM，CONNOR JR.Oligodendrocytes and myelination:the role of iron［J］.Glia，2009，57(5):467-478.
［15］　王位苹，汤庆娅.静脉补充铁剂防治早产儿缺铁性贫血的价值［J］.中华实用儿科临床杂志，2014，29(19):1497-1499.
WANG WP,TANG QY.Efficacy of intravenous iron for iron deficiency anemia on premature infants［J］.J Appl Clin Pediatr,2014,29(19):1497-1499.
［16］　梁秋冬，姬颖华，张小三.重组人红细胞生成素治疗肿瘤化疗相关性贫血388例［J］.新乡医学院学报，2010，27(3):261-263.
LIANG QD,JI YH,ZHANG XS.Evaluation of recombinant human erythropoietin in the treatment for 388 cases with chemotherapy-related anemia［J］.J Xinxiang Med Coll,2010,27(3):261-263.

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备注/Memo

备注/Memo:
武汉市卫计委基金资助（编号：WX14B05）
更新日期/Last Update: 2017-02-15