[1]韩敬力,刘天荣,易湘龙.鼠神经生长因子联合高压氧治疗视神经萎缩的疗效[J].眼科新进展,2016,36(9):832-834.[doi:10.13389/j.cnki.rao.2016.0222]
　HAN Jing-Li,LIU Tian-Rong,YI Xiang-Long.Effects of mouse nerve growth factor combined with hyperbaric oxygen therapy on optic atrophy[J].Recent Advances in Ophthalmology,2016,36(9):832-834.[doi:10.13389/j.cnki.rao.2016.0222]
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鼠神经生长因子联合高压氧治疗视神经萎缩的疗效
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年9期
页码:
832-834
栏目:
应用研究
出版日期:
2016-09-05

文章信息/Info

Title:
Effects of mouse nerve growth factor combined with hyperbaric oxygen therapy on optic atrophy
作者:
韩敬力; 刘天荣; 易湘龙
830002　新疆维吾尔自治区乌鲁木齐市，新疆医科大学第六附属医院眼科（韩敬力，刘天荣）；830054　新疆维吾尔自治区乌鲁木齐市，新疆医科大学第一附属医院眼科（易湘龙）
Author(s):
HAN Jing-Li;  LIU Tian-Rong ; YI Xiang-Long
Department of Ophthalmology , the Sixth Affiliated Hospital of Xinjiang Medical University ( HAN Jing-Li , LIU Tian-Rong) , Urumqi 830002 , Xinjiang Uygur Autonomous Region, China ; Department of Ophthalmology , the First Affiliated Hospital of Xinjiang Medical University ( YI Xiang-Long ) , Urumqi 830054 , Xinjiang Uygur Autonomous Region , China
关键词:
鼠神经生长因子; 高压氧; 视神经萎缩
Keywords:
mouse nerve growth factor;  hyperbaric oxygen; optic atrophy
分类号:
Ｒ７７４
DOI:
10.13389/j.cnki.rao.2016.0222
文献标志码:
A
摘要:
目的　探讨鼠神经生长因子（ｎｅｒｖｅｇｒｏｗｔｈｆａｃｔｏｒ，ＮＧＦ）联合高压氧治疗视神经萎缩的疗效。方法　将２０１２年６月至２０１５年５月我院收治的视神经萎缩患者７６例（８８眼），随机分成对照组和观察组，对照组３６例（４２眼），采用传统治疗加ＮＧＦ肌肉注射；观察组４０例（４６眼），在传统治疗加ＮＧＦ肌肉注射基础上联合使用高压氧治疗，比较分析２组疗效、治疗前后视力、视野改变及荧光充盈迟缓时间、视觉诱发电位（ＶＥＰ）Ｐ１００潜伏期等。结果　对照组治疗后总有效率７６．２％，观察组总有效率９３．５％，对照组疗效明显低于观察组，差异有统计学意义（Ｚ＝－２．０１０，Ｐ＝０．０４），总有效率对比差异亦有统计学意义（χ２＝５．２１，Ｐ＝０．０２）。病程≤２周的患者中，观察组疗效高于对照组，差异有统计学意义（χ２＝４．８３６，Ｐ＝０．０２８），但病程＞２周的总有效率两组比较差异则无统计学意义（Ｐ＞０．０５）。对照组与观察组不同病因的临床疗效比较，差异均无统计学意义（均为Ｐ＞０．０５）。两组视力、视野、眼底荧光充盈迟缓时间、ＶＥＰＰ１００潜伏期各项指标治疗前后比较差异均有统计学意义（均为Ｐ＜０．０１），提示对照组和观察组治疗均有效。比较对照组与观察组在治疗前的视力、视野、眼底荧光充盈迟缓时间、ＶＥＰＰ１００潜伏期各指标差异均无统计学意义（均为Ｐ＞０．０５），具有可比性；但在治疗后上述各项指标差异均有统计学意义（均为Ｐ＜０．０５）。结论　ＮＧＦ联合高压氧治疗视神经萎缩疗效确切，可促进视功能的恢复，值得临床上推广与应用。
Abstract:
Objective To investigate the effects of mouse nerve growth factor ( NGF) and hyperbaric oxygen therapy in patients with optic atrophy. Methods A total of 76 patients (88 eyes) with optic atrophy in our hospital from June 2012 to May 2015 were randomly divided into treatment group and control group. There were 36 patients (42 eyes) in the control group , using the traditional NGF therapy , and 40 patients (46 eyes) in treatment group , using the traditional NGF therapy combined with hyperbaric oxygen therapy. Visual acuity , visual field , and nipple fluorescence filling time , visual evoked potential ( VEP) and clinical efficacy were observed and compared after treatment in the two groups. Results The total effective rate in the treatment group ( 93. 5% ) was higher than that in the control group (76. 2% ) .the difference was statistically sigruficant (X2 = 5. 21 ,P = 0. 02) ; The clinical efficacy in the treatment group was higher than that in the control group, the difference was statistically sigruficant ( z = - 2. 010 .P = 0. 04 ) . The clinical efficacy in the patient with disease course less than or equal t0 2 weeks of the treatment group was significantly higher than that of the control group (X/ =4. 836 ,P = 0. 028 ) , but there was no statistical difference in the total effective rate in the patient with disease course more than 2 weeks between two groups (P > 0. 05 ) . There was no statistical difference in the clinical efficacy in the patients with different causes between two groups ( all P > 0. 05 ) . There were statistical differences in the visual acuity , visual field , papillary fluorescent filling time , VEP PlOO latency in two groups between before and after treatment ( all P < 0. 01 ) .there was no statistical difference in the above indexes before treatment between two groups ( all P > 0. 05 ) . and there were statistical differences after treatment between two groups ( all P < 0. 05 ) . Conclusion NGF combined with hyperbaric oxygen therapy is effective for optic atrophy , and can promote the recovery of visual function.

相似文献/References:

[1]畅立斌,鲍永珍,黎晓新,等.JNK细胞通路在高压氧和过氧化氢诱导人晶状体上皮细胞凋亡中的作用[J].眼科新进展,2014,34(10):923.[doi:10.13389/j.cnki.rao.2014.0255]
[2]申晓丽,樊宁,赵军,等.超声微泡造影剂联合鼠神经生长因子对高眼压兔视神经损害的保护作用[J].眼科新进展,2016,36(4):301.[doi:10.13389/j.cnki.rao.2016.0082]
　SHEN Xiao-Li,FAN Ning,ZHAO Jun,et al.Neuroprotective effects of ultrasonic microbubbles and mouse nerve growth factor on rabbit hypertension optic nerve damage[J].Recent Advances in Ophthalmology,2016,36(9):301.[doi:10.13389/j.cnki.rao.2016.0082]

备注/Memo

备注/Memo:
国家自然科学基金资助（编号：８１５６０１６１）
更新日期/Last Update: 2016-09-09