[1]郭俊国,赵晴,王兴荣,等.六锐胶囊对葡萄膜炎大鼠血清SOD、MDA和NT-3含量的影响[J].眼科新进展,2016,36(4):334-335.[doi:10.13389/j.cnki.rao.2016.0090]
　GUO Jun-Guo,ZHAO Qing,WANG Xing-Rong,et al.Effects of Liurui capsules on serum SOD, MDA and NT-3 content in rats with uveitis[J].Recent Advances in Ophthalmology,2016,36(4):334-335.[doi:10.13389/j.cnki.rao.2016.0090]
点击复制

六锐胶囊对葡萄膜炎大鼠血清SOD、MDA和NT-3含量的影响
分享到：

《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年4期
页码:
334-335
栏目:
实验研究
出版日期:
2016-04-05

文章信息/Info

Title:
Effects of Liurui capsules on serum SOD, MDA and NT-3 content in rats with uveitis
作者:
郭俊国; 赵晴; 王兴荣; 毕宏生
250002　山东省济南市，山东中医药大学眼科研究所（郭俊国，王兴荣，毕宏生）；250002　山东省济南市，山东省中西医结合眼病防治重点实验室（郭俊国，王兴荣，毕宏生）；250355　山东省济南市，山东中医药大学（赵晴）
Author(s):
GUO Jun-Guo; ZHAO Qing; WANG Xing-Rong ;  BI Hong-Sheng
Eye Institute ,Shandong University of Traditional Chinese Medicine (GUO Jun-Cuo , WANG Xing-Rong , BI Hong-Sheng ) , Jinan 250002. Shandong Province , China ; Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Westem Medicine for Prevention and Therapy of Ocular Diseases ( GUO Jun-Guo , WANG Xing-Rong, BI Hong-Sheng ) , Jinan 250002 . Shandong Province , China ; Shandong University of Traditional Chinese Medicine ( ZHAO Qing) , Jinan 250355 , Shandong Province , China
关键词:
六锐胶囊; 葡萄膜炎; 血清; 超氧化物歧化酶; 丙二醛; 神经营养素-3
Keywords:
liurui capsule ;  uveitis ;  serum ;  superoxide dismutase ;  malondialdehyde ;  neurotrophin-3
DOI:
10.13389/j.cnki.rao.2016.0090
文献标志码:
A
摘要:
目的　探讨六锐胶囊对葡萄膜炎大鼠血清超氧化物歧化酶（ｓｕｐｅｒｏｘｉｄｅｄｉｓ-ｍｕｔａｓｅ，ＳＯＤ）、丙二醛（ｍａｌｏｎａｌｄｅｈｙｄｅ，ＭＤＡ）和神经营养素-３（ｎｅｕｒｏｔｒｏｐｈｉｎ-３，ＮＴ-３）含量的影响。方法　采用光感受器间维生素Ａ类结合蛋白（ｉｎｔｅｒｐｈｏｔｏｒｅｃｅｐｔｏｒｒｅｔｉｎｏｉｄ-ｂｉｎｄｉｎｇｐｒｏ-ｔｅｉｎ，ＩＲＢＰ）制备葡萄膜炎大鼠模型，造模第２天开始给药，第１３天心脏取血，采用ＥＬＩＳＡ法检测六锐胶囊对葡萄膜炎大鼠血清ＳＯＤ、ＭＤＡ和ＮＴ-３含量的影响。结果　六锐胶囊不同剂量组、模型对照组的ＳＯＤ和ＮＴ-３含量均低于空白对照组，六锐胶囊不同剂量组的ＳＯＤ和ＮＴ-３含量均高于模型对照组，且随六锐胶囊剂量的增加，ＳＯＤ和ＮＴ-３含量均增加，差异均有统计学意义（均为Ｐ＜０．０５）。六锐胶囊不同剂量组、模型对照组的ＭＤＡ含量均高于空白对照组，六锐胶囊不同剂量组的ＭＤＡ含量均低于模型对照组，且随六锐胶囊剂量的增加，ＭＤＡ含量均下降，差异均有统计学意义（均为Ｐ＜０．０５）。结论　六锐胶囊可增加葡萄膜炎大鼠血清ＳＯＤ和ＮＴ-３含量，降低血清ＭＤＡ含量，具有抗氧化和视神经保护作用。
Abstract:
Objective To explore the effects of Liurui capsules on serum superoxide dismutase ( SOD) . malondialdehyde ( MDA) and neurotrophin-3 ( NT-3 ) content in rats with uveitis. Methods The uveitis models were established by using photoreceptors-binding protein ( IRBP1177-1191 ) .then the Liurui capsules were given at 2 days after modeling , and the blood was collected from heart at 13 days. ELISA was used to detect the SOD.MDA and NT-3 content in serum. Results The content of NT-3 and SOD in different dose group and model control group were lower than those in blank control group, and the content of NT-3 and SOD in different dose group were higher than those in model control group , and the content of NT-3 and SOD increased with the increase dose of Liurui capsule . and the differences were statistically significant ( all P < 0. 05 ) . The MDA content of different dose group and model control group were higher than those in blank control group , and the different dose group was lower than the model control group, and the content of MDA decreased with the increase dose of Liurui capsule , and the differences were statistically sigruficant ( all P < 0. 05 ) . Conclusion Liurui capsule can increase the serum SOD and NT-3 content, reduce the content of MDA.have the effects of antioxidant and neuroprotection.

相似文献/References:

[1]唐耀冰 陈桂英 王晓艳 侯明佳.玻璃体内注射Infliximab治疗大鼠葡萄膜炎的实验研究[J].眼科新进展,2013,33(7):000.
[2]罗文婷 孙大卫.血管黏附蛋白-1在眼科疾病中的研究进展[J].眼科新进展,2013,33(8):000.
[3]刘莹 李林 高晓唯.肿瘤坏死因子拮抗剂在葡萄膜炎治疗中的应用[J].眼科新进展,2012,32(1):000.
[4]刘莹 李林 高晓唯 张振华 杨永利 赵旭东.玻璃体内注射 Infliximab对实验性自身免疫性葡萄膜炎的治疗作用[J].眼科新进展,2012,32(2):000.
[5]陈海婷,王红.生物制剂在葡萄膜炎治疗中的应用[J].眼科新进展,2010,30(5):000.
[6]杨婷婷,邓娟,梁雪梅. 葡萄膜炎患者血清胆红素、尿酸及白蛋白浓度分析[J].眼科新进展,2014,34(4):358.[doi:10.13389/j.cnki.rao.2014.0097]
[7]于晋懿,卢弘. 非感染性葡萄膜炎的免疫抑制治疗[J].眼科新进展,2014,34(7):695.[doi:10.13389/j.cnki.rao.2014.0191]
[8]郭建全.曲安奈德对年龄相关性白内障术后前葡萄膜炎的疗效及其对炎症因子的影响[J].眼科新进展,2014,34(8):769.[doi:10.13389/j.cnki.rao.2014.0212]
　GUO Jian-Quan.Efficacy of triamcinolone acetonide for anterior uveitis after age-related cataract surgery and its impact on inflammatory cytokines[J].Recent Advances in Ophthalmology,2014,34(4):769.[doi:10.13389/j.cnki.rao.2014.0212]
[9]张沐,康丽华,管怀进.MicroRNA相关单核苷酸多态性与眼部疾病关系的研究进[J].眼科新进展,2014,34(11):1083.[doi:10.13389/j.cnki.rao.2014.0301]
　ZHANG Mu,KANG Li-Hua,GUAN Huai-Jin.Recent advances in relationship between microRNA-related SNPs and ocular diseases[J].Recent Advances in Ophthalmology,2014,34(4):1083.[doi:10.13389/j.cnki.rao.2014.0301]
[10]张莲,毕宏生,郭俊国.抗TNF生物制剂在葡萄膜炎临床治疗中的应用进展[J].眼科新进展,2014,34(12):1187.[doi:10.13389/j.cnki.rao.2014.0330]
　ZHANG Lian,BI Hong-Sheng,GUO Jun-Guo.Application progress of anti-TNF biologic agents for uveitis[J].Recent Advances in Ophthalmology,2014,34(4):1187.[doi:10.13389/j.cnki.rao.2014.0330]

备注/Memo

备注/Memo:
山东省重点研发计划项目资助（编号：２０１５ＧＧＨ３１９００１）
更新日期/Last Update: 2016-04-01