[1]王妍茜,康刚劲.Nrf2/Keap1抗氧化系统与白内障[J].眼科新进展,2016,36(3):291-294.[doi:10.13389/j.cnki.rao.2016.0079]
　WANG Yan-Xi,KANG Gang-Jin.Nrf2/Keapl antioxidant system and cataract[J].Recent Advances in Ophthalmology,2016,36(3):291-294.[doi:10.13389/j.cnki.rao.2016.0079]
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Nrf2/Keap1抗氧化系统与白内障
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
36卷
期数:
2016年3期
页码:
291-294
栏目:
文献综述
出版日期:
2016-03-05

文章信息/Info

Title:
Nrf2/Keapl antioxidant system and cataract
作者:
王妍茜; 康刚劲
646000　四川省泸州市，泸州医学院附属医院眼科
Author(s):
WANG Yan-Xi ;  KANG Gang-Jin
Department of Ophthatmology, the Affiliated Hospital of Luzhou Medical College , Luzhou 646000 . Sichuan Province . China
关键词:
Nrf2; Keap1; 白内障; 氧化应激
Keywords:
Nrf2 ;  Keapl ;  cataract ;  oxidative stress
DOI:
10.13389/j.cnki.rao.2016.0079
文献标志码:
A
摘要:
Ｎｒｆ２／Ｋｅａｐ１系统被认为是机体抗氧化机制中最重要的通路，该通路的激活及其与其他通路相互作用是阻止白内障发生发展的重要机制。研究表明，Ｎｒｆ２／Ｋｅａｐ１抗氧化系统结构功能异常、去甲基化的启动与加速及Ｔｅｔ１的异常激活与白内障的发生发展密切相关。本文就Ｎｒｆ２／Ｋｅａｐ１系统与白内障发生发展的关系及其相关机制进行综述。
Abstract:
Nrf2/Keapl system is considered to be the most important pathway in the mechanism of antioxidant, the activation of this pathway and its interaction with other pathways are the important mechanisms to prevent the development of cataract. Studies have shown that the abnormal structure and function of Nrfl/Keapl antioxidant system , starting and accelerating methylation and Tetl activation is closely related to the occurrence of cataract development. This article reviews the relationship between Nrf2/Keapl system and development of cataract and its related mechanisms.

相似文献/References:

[1]杨艳,于海涛,杭丽,等.槲皮素磷脂复合物激活Nrf2信号通道增强对氧化损伤ARPE-19细胞的保护作用[J].眼科新进展,2016,36(10):923.[doi:10.13389/j.cnki.rao.2016.0247]
　YANG Yan,YU Hai-Tao,HANG Li,et al.Protective effects of quercetin phospholipid complex on oxidative injury in ARPE-19 cells associated with activation of Nrf2 pathway[J].Recent Advances in Ophthalmology,2016,36(3):923.[doi:10.13389/j.cnki.rao.2016.0247]

备注/Memo

备注/Memo:
泸州医学院附属医院国际合作课题（编号：１１１２７）
更新日期/Last Update: 2016-03-08