[1]文中华,李淑琳,张玉明,等.原发性干燥综合征干眼的中西医结合治疗临床研究[J].眼科新进展,2015,35(12):1166-1169.[doi:10.13389/j.cnki.rao.2015.0319]
　WEN Zhong-Hua,LI Shu-Lin,ZHANG Yu-Ming,et al.Traditional Chinese medicine and Western medicine treatment of dry eye in primary Sjogren’ s syndrome[J].Recent Advances in Ophthalmology,2015,35(12):1166-1169.[doi:10.13389/j.cnki.rao.2015.0319]
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原发性干燥综合征干眼的中西医结合治疗临床研究
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年12期
页码:
1166-1169
栏目:
应用研究
出版日期:
2015-12-05

文章信息/Info

Title:
Traditional Chinese medicine and Western medicine treatment of dry eye in primary Sjogren’ s syndrome
作者:
文中华; 李淑琳; 张玉明; 杨敏
541001　广西壮族自治区桂林市，桂林医学院附属医院眼科
Author(s):
WEN Zhong-Hua ;  LI Shu-Lin ; ZHANG Yu-Ming ;  YANG Min
Department of Ophthalmology, the Affiliated Hospital of Guilin Medical College , Guilin 541001 , Guangxi Zhuang Autonomous Region , China
关键词:
原发性干燥综合征干眼; 中西医结合综合疗法; 润目丰液汤
Keywords:
dry eye in primary Sjogren’ s syndrome; Traditional Chinese medicine and Western medicine treatment ;  Runmufengye soup
DOI:
10.13389/j.cnki.rao.2015.0319
文献标志码:
A
摘要:
目的　观察中西医综合疗法治疗原发性干燥综合征干眼的临床效果。方法　采用前瞻性病例对照研究。纳入患者１１０例２２０眼，治疗组及对照组各５５例１１０眼。对照组给予羟糖甘滴眼液、重组牛碱性成纤维细胞生长因子眼用凝胶、睑板腺按摩治疗。治疗组与对照组相同用药及睑板腺按摩治疗的同时，内服润目丰液汤治疗。统计每例患者双眼的每项评价指标数值－干眼症状评分、泪膜破裂时间、ＳｃｈｉｒｍｅｒⅠ试验（无表面麻醉下）、角膜荧光素染色评分，并对数据进行统计学分析。结果　治疗组与对照组治疗前干眼症状评分、泪膜破裂时间、ＳｃｈｉｒｍｅｒⅠ试验、角膜荧光素染色评分差异均无统计学意义（均为Ｐ＞０．０５）；两组治疗后１周、４周、８周上述各指标随治疗时间的延长较治疗前均有好转，除对照组治疗后１周干眼症状评分与治疗前差异无统计学意义（Ｐ＞０．０５）外，其他时间点各指标与治疗前差异均有统计学意义（均为Ｐ＜０．０５），治疗后相同时间点治疗组上述各指标均优于对照组（均为Ｐ＜０．０５）。结论　中西医综合治疗能标本兼顾，更好地改善原发性干燥综合征干眼的临床症状，治疗效果明显。
Abstract:
Objective To observe the therapeutic effects of Traditional Chinese medicine( TCM) combined with Western medicine in the treatment of dry eye in primary Sjogren’ s syndrome. Methods A Case-control study was employed. 110 patients (220 eyes) were averagely divided into two groups,55 cases ( 110 eyes) in each group. The control group were treated with Hypromellose 29IO.Dextran 70 and Glycerol eye drops , recombinant bovine basic fibroblast growth factor eye gel, tarsal massage therapy. The treatment group received the same treatment as the control group , additionally drunk traditional Chinese medicine Runmufengye soup. The dry eye symptom scores, tear film break-up time . Schirmer I test under no topical anesthesia and corneal fluorescein stairung were observed and analyzed. Results There was no statistically significant difference in dry eye symptoms score , tear film break-up time . Schirmer I test.corneal fluorescein staining score between the treatment group and control group before treatment ( all P > 0. 05 ) . After treatment of I weeks ,4 weeks , 8 weeks. each index improved over time in the two groups, and there were statistical differences compared with pre-treatment except for I week of the control group ( all P < 0. 05 ) . The therapeutic effects of the treatment group were better than those of the control group ( all P < 0. 05 ) . Conclusion The effect of integrated traditional Chinese medicine and Western mediane treatment can concordance between the outside and the inside. It was obviously better than that of the Western mediane treatment in improving symptoms and clinical signs of dry eye in primary Sjogren ’ s syndrome.

备注/Memo

备注/Memo:
广西卫生厅科研项目资助（编号：Ｚ２０１０３０７）；桂林市科技计划项目资助（编号：２０１４０１２０-１-６）
更新日期/Last Update: 2015-12-07