[1]赵武校,蓝方方,李志超,等.波前像差在屈光参差性弱视光学质量评估中的应用[J].眼科新进展,2015,35(10):939-944.[doi:10.13389/j.cnki.rao.2015.0256]
　ZHAO Wu-Xiao,LAN Fang-Fang,LI Zhi-Chao,et al.Application of wavefront aberration in optical quality assessment for anisometropic amblyopia[J].Recent Advances in Ophthalmology,2015,35(10):939-944.[doi:10.13389/j.cnki.rao.2015.0256]
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波前像差在屈光参差性弱视光学质量评估中的应用
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年10期
页码:
939-944
栏目:
应用研究
出版日期:
2015-10-05

文章信息/Info

Title:
Application of wavefront aberration in optical quality assessment for anisometropic amblyopia
作者:
赵武校; 蓝方方; 李志超; 甘露; 刘伟民
530021　广西壮族自治区南宁市，广西壮族自治区人民医院视光科　广西视光中心
Author(s):
ZHAO Wu-Xiao ;  LAN Fang-Fang ;  LI Zhi-Chao ;  GAN Lu ;  LIU Wei-Min
Center of Optometry and Visual Science , Department of Optometry , People ’ s Hospital of Guangxi Zhuang Autonomous Region , Nanning 530021 , Guangxi Zhuang Autonomous Region , China
关键词:
屈光参差性弱视; 波前像差; 最佳矫正视力; 等效离焦度
Keywords:
anisometropic amblyopia ;  wavefront aberration ;  best corrected visual acuity ;  defocus equivalent
DOI:
10.13389/j.cnki.rao.2015.0256
文献标志码:
A
摘要:
目的　探讨屈光参差性弱视双眼间的波前像差差异以及临床特点。方法　选取５３例屈光参差性弱视患者，年龄９～４０岁，其中男３１例，女２２例，纳入本横断面研究。所有患者均接受ＷａｖｅＳｃａｎ波前像差检查，弱视眼与对侧眼之间的波前像差差异采用配对ｔ检验；波前像差参数值、等效离焦度、最佳矫正视力，以及年龄之间的关系采用相关分析。然后将中度弱视患者按照年龄分为成年弱视组和儿童弱视组，分析这两组的临床特点。结果　经配对ｔ检验显示，５３例患者的弱视眼与对侧眼在最佳矫正视力、等效离焦度、总像差、总高阶像差、三叶草像差、三阶像差均方根值等指标上差异均有统计学意义（均为Ｐ＜０．０５）。成年弱视组与儿童弱视组内均未发现年龄与高阶像差参数之间存在相关性。成年弱视组弱视眼与对侧眼之间在总像差（Ｐ＝０．０００）、三叶草像差（Ｐ＝０．０４７）和三阶像差均方根值（Ｐ＝０．０３２）上差异均有统计学意义（均为Ｐ＜０．０５）；儿童弱视组弱视眼与对侧眼之间在总像差（Ｐ＝０．０００）、球差（Ｐ＝０．００８）和四阶像差均方根值（Ｐ＝０．０３２）上差异均有统计学意义（均为Ｐ＜０．０５）。两个年龄组内的相关回归分析显示，在成年弱视组，等效离焦度与总像差有相关性（Ｐ＜０．０１），最佳矫正视力与总像差、球差均有相关性（均为Ｐ＜０．０５）；且等效离焦度与总像差的回归方程为ｙ＝３．３４３＋０．９４２ｘ（Ｆ＝４０．８３０、Ｐ＝０．０００、Ｒ２＝０．６７１），最佳矫正视力与总像差的回归方程为ｙ＝０．３２１＋０．０１７ｘ（Ｆ＝５．０５８、Ｐ＝０．０３６、Ｒ２＝０．２０２）。在儿童弱视组，等效离焦度与总像差、总高阶像差均有相关性（均为Ｐ＜０．０５），最佳矫正视力与五阶像差均方根值存在相关性（Ｐ＜０．０１）；等效离焦度与总像差的回归方程为ｙ＝１．５２９＋１．１７６ｘ（Ｆ＝１７．０９０、Ｐ＝０．００１、Ｒ２＝０．５０１），最佳矫正视力与五阶像差均方根值的回归方程为ｙ＝０．００６＋０．１４３ｘ（Ｆ＝１０．８５１、Ｐ＝０．００４、Ｒ２＝０．３９０）。结论　除最佳矫正视力、等效离焦度、总像差之外，屈光参差性弱视患者双眼间的高阶像差存在显著差异；对于中度弱视患者，双眼间高阶像差差异在成人与儿童表现不同。
Abstract:
Objective To investigate the differences of wavefront aberrations and clinical profile in arusometropic amblyopia. Methods Fifty-three patients with anisometropic amblyopia aged 9 t0 40 years old,31 males and 22 females.were enrolled in our cross-sectional study. All patients were examined by WaveScan ~ Wavefront system. Paired t-test was used to compare the differences of wavefront aberration parameters between amblyopic and fellow eyes , and correlation analysis were used among age, best corrected visual acuity ( BCVA) , defocus equivalent( DE ) , and wavefront aberration parameters. Then moderate amblyopic patients were selected and divided into children and adults groups according to their age , and their interocular differences and relationships were also analyzed within groups. Results Sigruficant differences were found in BCVA , DE .total aberration . total higher order root mean square ( RMS ) . trefoil . and third order RMS between amblyopic and fellow eyes of the whole anisometropic amblyopes. But no relationship was noted between age and higher order aberration parameters in both eyes of anisometropic amblyopia. When moderate amblyopia split into adults and children groups , sigruficant differences in total aberration ( P = 0. 000 ) . trefoil ( P = 0. 047 ) . and 3rd RMS(P = 0. 032) were found between amblyopic and fellow eyes of adults group. By contrast , significant differences in total aberration( P = 0. 000 ) , spherical aberration ( P = 0. 008 ) , and 4th RMS ( P = 0. 032 ) were observed between amblyopic and fellow eyes of children group. Furthermore .in adults group , statistically significant associations between DE and total aberration ( P < 0. 01 ) . between BCVA and total aberration , and spherical aberration ( both P < 0. 05 ) were noted in amblyopic eye , and the linear regression equation between DE and total aberration was y = 3. 343 + 0. 942x ( F = 40. 830 ,P = 0. 000 .R2 = 0. 671) . between BCVA and total aberration was y = 0. 321 + 0. 017x ( F = 5. 058 , P = 0. 036 . R2 = 0. 202 ) . In children group , significant associations were observed between DE and total aberration, and higher order aberrations ( all P < 0. 05 ) ,between BCVA and 5th RMS (P < 0. 01) in amblyopic eye , and the linear regression equation between DE and total aberration was y = 1. 529 + 1. 176x(F= 17. 090 .P = 0. 001 ,R2 = 0. 501 ) . between BCVA and 5th RMS was y = 0. 006 + 0. 143x (F= 10. 851 ,P = 0. 004 .R2 = 0. 390 ) . Conclusion Except for BCVA. DE and total aberration. anisometropic amblyopia manifest significant interocular differences in higher order aberrations , and the asymmetry in pattern of higher order aberrations is different between adults and children with moderate anisometropic amblyopia.

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备注/Memo

备注/Memo:
广西壮族自治区卫生厅资助项目（编号： 桂卫Ｚ２０１３３３６）；广西壮族自治区人民医院青年基金项目
更新日期/Last Update: 2015-09-30