[1]李建华,杨阳,王大庆,等. 水液缺乏型干眼症患者下泪新月高度临床对比分析[J].眼科新进展,2015,35(8):778-780.[doi:10.13389/j.cnki.rao.2015.0214]
　LI Jian-Hua,YANG Yang,WANG Da-Qing,et al. Clinical analysis of lower tear meniscus height in aqueous tear deficiency dry eye patients[J].Recent Advances in Ophthalmology,2015,35(8):778-780.[doi:10.13389/j.cnki.rao.2015.0214]
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 水液缺乏型干眼症患者下泪新月高度临床对比分析
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年8期
页码:
778-780
栏目:
应用研究
出版日期:
2015-08-05

文章信息/Info

Title:
 Clinical analysis of lower tear meniscus height in aqueous tear deficiency dry eye patients
作者:
 李建华; 杨阳; 王大庆; 杨小丽; 兰长骏
 637000　四川省南充市，川北医学院附属医院眼科
Author(s):
 LI Jian-Hua; YANG Yang; WANG Da-Qing ; YANG Xiao-Li ;  LAN Chang-Jun
 Department of Ophthalmology ,the Affiliated Hospital of North Sichuan Medical College , Nanchong 637000 . Sichuan Province , China
关键词:
 ; 泪新月; 水液缺乏型干眼症; 眼前节光学相干断层扫描仪
Keywords:
 ; tear meniscus ;  aqueous tear deficiency dry eye ;  anterior segment optical coherence tomography
DOI:
10.13389/j.cnki.rao.2015.0214
文献标志码:
A
摘要:
 目的　比较水液缺乏型干眼症（ａｑｕｅｏｕｓｔｅａｒｄｅｆｉｃｉｅｎｃｙ，ＡＴＤ）患者与非ＡＴＤ人群的下泪新月高度（ｌｏｗｅｒｔｅａｒｍｅｎｉｓｃｕｓｈｅｉｇｈｔ，ＬＴＭＨ），并分析ＬＴＭＨ用于ＡＴＤ诊断的可行性。方法　选取２０１３年５月至９月于我院眼科门诊确诊的ＡＴＤ患者４０例（４０眼）作为ＡＴＤ组，另选取３９例（３９眼）非ＡＴＤ人群作为对照组，分别用眼前节光学相干断层扫描仪获取被检者自然瞬目后的下泪新月图像并测量ＬＴＭＨ。通过绘制诊断试验特征曲线并计算线下面积，计算并选择ＬＴＭＨ的“异常”临界值，同时得出相应的敏感性（ＡＴＤ患者中ＬＴＭＨ值呈阳性的比率）与特异性（非ＡＴＤ人群中ＬＴＭＨ值呈阴性的比率）值，以此确定ＬＴＭＨ是否可作为诊断ＡＴＤ的有效指标。结果　ＡＴＤ组的ＬＴＭＨ为（１４１．１±２２．４）μｍ，对照组为（１９３．９±２２．３）μｍ，２者差异有统计学意义（ｔ＝１０．４９５，Ｐ＜０．０１）。当ＬＴＭＨ选择“异常”临界值为０．１６８ｍｍ时，其对于ＡＴＤ的诊断敏感性为９２．３％，特异性为９２．５％。结论　ＡＴＤ患者的泪新月明显小于非ＡＴＤ人群，ＬＴＭＨ对于ＡＴＤ有良好的诊断准确性，因此用作ＡＴＤ的诊断指标具有可行性。
Abstract:
 Objective To compare the lower tear meniscus height ( LTMH) between aqueous tear deficiency ( ATD) dry eye patients and non-ATD subjects , and analyze its potential in the diagnosis of ATD. Methods Forty eyes of 40 ATD patients collected between May to September 2013 constituted ATD group , which were compared with control group consisted of 39 eyes from 39 non-ATD subjects. Lower tear meniscus was imaged by anterior segment optical coherence tomography ( AS-OCT) immediately after normal blink , and LTMH was measured. For LTMH used for diagnosing ATD , receiver operating characteristic ( ROC) curve was plotted and area under the ROC curve (AUC) was calculated. When the cut-off value of LTMH for L abnormal’ was figured out.sensitivity ( the ratio of patients with ATD who were positive for the variable ) and specificity ( the ratio of non-ATD subjects who were negative for the variable) were also calculated. Results LTMH in ATD group was ( 141. I + 22. 4) ym, and which in control group was ( 193. 9 + 22. 3 ) ym. LTMH was sigruficantly smaller in ATD group than control group ( t = 10. 495 , P < 0. 01) . LTMH showed 92. 3% of sensitivity and 92. 5% of specificity for diagnosing ATD when the cut-off value for L abnormal ’ was 0. 168 mm. Coriclrisiori The tear meruscus is smaller in patients with ATD compared with non-ATD subjects. LTMH shows good diagnostic accuracy for ATD and which has potential in the diagnosis of ATD.

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备注/Memo

备注/Memo:
 川北医学院科研发展计划项目（编号：ＣＢＹ１２－Ａ－ＱＮ０９）
更新日期/Last Update: 2015-07-31