[1]程广文,朱豫. 泪腺炎患者血清性激素变化及其与γ-IFN、IL-4的相关性[J].眼科新进展,2015,35(6):561-565.[doi:10.13389/j.cnki.rao.2015.0152]
　CHENG Guang-Wen,ZHU Yu. Changes of sexual hormone in dacryoadenitis patients and its correlation with γ-IFN,IL-4 levels in serum[J].Recent Advances in Ophthalmology,2015,35(6):561-565.[doi:10.13389/j.cnki.rao.2015.0152]
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 泪腺炎患者血清性激素变化及其与γ-IFN、IL-4的相关性
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
35卷
期数:
2015年6期
页码:
561-565
栏目:
应用研究
出版日期:
2015-06-05

文章信息/Info

Title:
 Changes of sexual hormone in dacryoadenitis patients and its correlation with γ-IFN,IL-4 levels in serum
作者:
 程广文; 朱豫
 450052　河南省郑州市，郑州大学第一附属医院眼科
Author(s):
 CHENG Guang-Wen ; ZHU Yu
 Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052.Henan Province. China
关键词:
 ; 泪腺炎; 雌二醇; 睾酮; 泌乳素; γ-IFN; IL-4
Keywords:
 ; dacryoadenitis ;  estradiol;  testosterone ;  prolactin ; γ-interferon ;  interleukin-4
DOI:
10.13389/j.cnki.rao.2015.0152
文献标志码:
A
摘要:
 目的　观察泪腺炎患者血清中雌二醇（ｅｓｔｒａｄｉｏｌ，Ｅ２）、睾酮（ｔｅｓｔｏｓｔｅｒｏｎｅ，Ｔ）、泌乳素（ｐｒｏｌａｃｔｉｎ，ＰＲＬ）水平的变化，并探讨这种变化与血清中γ-干扰素（γ-ｉｎｔｅｒｆｅｒｏｎ，γ-ＩＦＮ）、白细胞介素-４（ｉｎｔｅｒｌｅｕｋｉｎ-４，ＩＬ-４）变化的关系。方法　收集４２例２０１３年１１月至２０１４年１０月我院确诊为泪腺炎的患者炎症期（炎症期组）与炎症缓解期（缓解期组）的血清，４０例同年龄段于我院体检的正常人血清作为正常对照组，采用电化学发光法检测血清中Ｅ２、Ｔ、ＰＲＬ的水平，酶联免疫吸附法测定血清中γ-ＩＦＮ、ＩＬ-４水平。结果　泪腺炎患者炎症期组血清Ｅ２、ＰＲＬ水平分别为（６４．１２±３５．９２）ｎｇ?Ｌ－１和（１７．６３±８．５９）μｇ?Ｌ－１，显著高于缓解期组的（４３．１６±２６．５７）ｎｇ?Ｌ－１和（１０．３０±５．５９）μｇ?Ｌ－１及正常对照组的（４１．９２±２１．６８）ｎｇ?Ｌ－１和（９．０８±２．６１）μｇ?Ｌ－１，差异均有统计学意义（均为Ｐ＜０．０５）；炎症期组与缓解期组血清Ｔ分别为（０．８０±１．３６）μｇ?Ｌ－１和（０．７９±１．４２）μｇ?Ｌ－１，与正常对照组的（１．７６±２．４９）μｇ? Ｌ－１相比差异均有统计学意义（均为Ｐ＜０．０５）。炎症期组血清γ-ＩＦＮ、ＩＬ-４水平分别为（３５３．１２±１０８．３６）ｎｇ?Ｌ－１和（１２００．４３±３１４．６９）ｎｇ?Ｌ－１，显著高于缓解期组的（１９２．６８±４３．１６）ｎｇ?Ｌ－１和（９１９．３８±２２７．１６）ｎｇ?Ｌ－１及正常对照组的（１９０．９３±３６．４０）ｎｇ?Ｌ－１和（８５３．３７±１７２．３１）ｎｇ?Ｌ－１，差异均有统计学意义（均为Ｐ＜０.０５）。Ｅ２与γ-ＩＦＮ、ＩＬ-４水平呈正相关（均为Ｐ＜０．０５）；Ｔ与γ-ＩＦＮ、ＩＬ-４水平呈负相关（均为Ｐ＜０．０５）；ＰＲＬ与γ-ＩＦＮ、ＩＬ-４水平呈正相关（均为Ｐ＜０．０５）。女性患者炎症期组血清γ-ＩＦＮ水平为（３４４．４６±１１２．０６）ｎｇ?Ｌ－１，高于男性的（２９２．９８±７１．２７）ｎｇ?Ｌ－１（Ｐ＜０．０５），Ｅ２／Ｔ比值为６６５．３６，明显高于男性的１３．９１（Ｐ＜０．０５）。结论　泪腺炎患者血清中性激素Ｅ２、ＰＲＬ的升高、Ｔ的降低及Ｅ２／Ｔ比例失调可能介导Ｔｈ１、Ｔｈ２细胞免疫通路的平衡紊乱从而致病。女性体内高水平的雌激素可能是导致女性易患自身免疫性疾病的主要原因。
Abstract:
 Objective To investigate serum level of estradiol ( E2 ) , testosterone ( T) ,prolactin ( PRL) in dacryoadenitis patients . and study its correlation with γ-interferon ( 7-IFN) .interleukin-4 ( IL-4 ) levels in serum. Methods The blood samples of a total 42 patients with dacryoadenitis were collected in our hospital from November 2013 to October 2014 in inflammation stage and remission stage , and blood samples from another 40 normal cases were set as normal control group. The serum levels of E2 ,T and PRL were determined by electrochemilununescence rmmunoassay ,γ一IFN and IL-4 levels in serum were measured by ELISA. Results The serum level of E2 . PRL, l,-IFN and IL-4 in inflammation stage group of dacryoadenitis patients were ( 64. 12 + 35. 92) ng . 1’1 .(17. 63 +8. 59) Vg . L-1 , (353. 12 + 108. 36) ng . L’I , ( 1200. 43 +314. 69) ng . L-l , respectively , were much higher than those in renussion stage group [ ( 43. 16 + 26. 57 ) ng . L-l , ( 10. 30 +5. 59) Vg . L-1 , ( 192. 68 + 43. 16) ng . L-l , (919. 38 + 227. 16) ng . L’l ] and the normal control group [ (41. 92 + 21. 68 ) ng . L-1 , ( 9. 08 + 2. 61 ) vg . L-l , ( 190. 93 + 36. 40) ng . L’l , ( 853. 37 + 172. 31) ng . L-l ] ( all P < 0. 05 ) ; While the levels of T in inflammation [ ( 0. 80 + 1. 36) Vg . L -l ] and remission stage group [ (0. 79 + 1. 42) vg . L-I ] were significantly lower than those in the normal control group [ ( 1. 76 + 2. 49) yg . L-l ] ( all P < 0. 05 ) . The serum levels of E2 had a positive correlation with those of 7-IFN and IL-4 ( all P < 0. 05 ) ; On the contrary, T had a negative correlation with the serum levels of 7-IFN and IL-4 ( all P < 0. 05 ) ; PRL had a positive correlation with 7-IFN and IL-4 ( all P < 0. 05 ) . E2/T had a positive correlation with 7-IFN and IL-4 ( all P < 0. 05 ) .^y一IFN [ ( 344. 46 + 112. 06) ng . L ’l ] and E2/T( 665. 36 ) of female patients in inflammation stage group were significantly higher than those of male [ ( 292. 98 + 71. 27) ng . L -l and 13. 91 ] ( all P < 0. 05 ) . Conclusion The rise of E2 and PRL, the fall of T and the imbalance of E2/T in patients with dacryoadenitis probably mediate the disorders of Thl .Th2 immune pathways and cause the disease. The immune response of Thl cells in women ’ s body may be fiercer than men. and a high level of estrogen in women is probably the major reason that women are susceptible to autoimmune diseases.

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更新日期/Last Update: 2015-06-01