[1]奉红波.脑蛋白水解物与鼠神经生长因子对青光眼术后视神经的保护作用[J].眼科新进展,2014,34(5):477-479.[doi:10.13389/j.cnki.rao.2014.0131]
　FENG Hong-Bo.Protective effects of cerebroprotein hydroly-sate and mouse nerve growth factor on optic nerve after anti-glaucoma surgery[J].Recent Advances in Ophthalmology,2014,34(5):477-479.[doi:10.13389/j.cnki.rao.2014.0131]
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脑蛋白水解物与鼠神经生长因子对青光眼术后视神经的保护作用
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
34卷
期数:
2014年5期
页码:
477-479
栏目:
应用研究
出版日期:
2014-05-05

文章信息/Info

Title:
Protective effects of cerebroprotein hydroly-sate and mouse nerve growth factor on optic nerve after anti-glaucoma surgery
作者:
奉红波
５４５００１　广西柳州市，柳州市中医院眼科
Author(s):
FENG Hong-Bo
关键词:
青光眼; 脑蛋白水解物注射剂; 注射用鼠神经生长因子; 视神经保护
Keywords:
glaucoma;  cerebroprotein hydrolysate injection;  injectable mouse nerve growth factor ;  optic neuroprotection
DOI:
10.13389/j.cnki.rao.2014.0131
文献标志码:
A
摘要:
目的　比较脑蛋白水解物与鼠神经生长因子对原发性闭角型青光眼术后视神经的保护作用。方法　选取２０１１年１ 月至２０１２年１２月我院小梁切除术后原发性闭角型青光眼患者８０例（８０眼），随机分成脑蛋白水解物组与鼠神经生长因子组。脑蛋白水解物组给予脑蛋白水解物注射剂，鼠神经生长因子组给予注射用鼠神经生长因子，均连续治疗４周。比较两组治疗前及治疗后１个月的视力、眼压、视野、视觉诱发电位等。结果　脑蛋白水解物组患者治疗前视力为０．３８±０．４０，治疗后１个月为０．５１±０．３８，治疗后显著高于治疗前，差异有统计学意义（Ｐ＝０．０４０）；鼠神经生长因子组治疗前视力为０．４６±０．３３，治疗后１ 个月为０．４８±０．３５，差异无统计学意义（Ｐ＝０．５５２）；脑蛋白水解物组治疗后视力显著高于鼠神经生长因子组，差异有统计学意义（Ｐ＝０．０４６）。脑蛋白水解物组患者治疗后１个月的平均视敏度、Ｐ１００波振幅显著高于治疗前（Ｐ＝０．０００、０．０２８），视野平均缺损值、Ｐ１００波潜伏期显著低于治疗前（Ｐ＝０．０００、０．０００）；鼠神经生长因子组患者治疗后的平均视敏度、Ｐ１００波振幅显著高于治疗前（Ｐ＝０．０２１、０．０４５），Ｐ１００波潜伏期显著低于治疗前（Ｐ＝０．０２６）。脑蛋白水解物组治疗后的视力、平均视敏度、Ｐ１００ 波振幅显著高于鼠神经生长因子组（Ｐ＝０．０４６、０．００３、０．０１２），视野平均缺损值、Ｐ１００波潜伏期显著低于鼠神经生长因子组（Ｐ＝０．０３６、０．０３２）。结论　脑蛋白水解物注射液与注射用鼠神经生长因子均可稳定患者视力，改善视野，促进部分视神经功能的恢复，但脑蛋白水解物注射液作用明显优于注射用鼠神经生长因子。
Abstract:
Objective To compare the protective effects of cerebroprotein hydrolysate ( CH) and mouse nerve growth factor ( NGF) on optic nerve after anti-glaucoma surgery of primary close-angle glaucoma patients. Methods Eighty cases ( 80 eyes) with primary close-angle glaucoma underwent trabeculectomy in our hospital from January 2011 to December 2012 were randomly divided into CH group and NGF group. The patients in CH group were treated with CH injection, and NGF group were treated with injectable mouse NGF. all continuous treating time were 4 weeks. The vision. intraocular pressure , visual field , visual evoked potential were compared before and after treatment in two groups. Results The vision before treatment and I month after treatment in CH group were 0. 38 +0. 40 and 0. 51 + 0. 38 , respectively, there was statistical difference (P = 0. 040) , which in NGF group were 0. 46 + 0. 33 and 0. 48 + 0. 35 , respectively , there was no statistical difference ( P = 0. 552 ) . The vision after treatment in CH group was better than that in NGF group , there was statistical difference (P = 0. 046 ) . The mean sensitivity, amplitude of PlOO wave at I month after treatment in CH group were sigruficantly higher than those before treatment ( P =0. 000 .0. 028 ) , and mean defect of visual field , latency of PlOO wave were sigruficantly lower than those before treatment (P = 0. 000 ,0. 000) . The mean sensitivity , amplitude of PlOO wave at I month after treatment in NGF group was significantly higher than those before treatment (P = 0. 021 .0. 045 ) , and latency of PlOO wave was significantly lower than that before treatment( P = 0. 026) . The vision. mean sensitivity , amplitude of PlOO wave after treatment in CH group were significantly higher than those in NGF group after treatment ( P = 0. 046 ,0. 003 .0. 012) . and mean defect of visual field.latency of PlOO wave in CH group were significantly lower than those in NGF group ( P = 0. 036 .0. 032) . Conclusion CH injection and injectable mouse NGF all can stabilize vision , improve visual field . enhance electrical activity of optic nerve and promote part of visual functional recover , but CH injection is much better than injectable mouse NGF.

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更新日期/Last Update: 2014-05-04