[1]鲍思洁,李鹏飞,康丽华,等.RNA甲基化N6-甲基腺苷修饰在眼部疾病中作用的研究进展[J].眼科新进展,2023,43(5):401-406.[doi:10.13389/j.cnki.rao.2023.0081]
　BAO Sijie,LI Pengfei,KANG Lihua,et al.Research progress in the effect of ribonucleic acid methylation N6-methyladenosine modification on eye diseases[J].Recent Advances in Ophthalmology,2023,43(5):401-406.[doi:10.13389/j.cnki.rao.2023.0081]
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RNA甲基化N6-甲基腺苷修饰在眼部疾病中作用的研究进展/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年5期
页码:
401-406
栏目:
文献综述
出版日期:
2023-05-05

文章信息/Info

Title:
Research progress in the effect of ribonucleic acid methylation N6-methyladenosine modification on eye diseases
作者:
鲍思洁; 李鹏飞; 康丽华; 王从玉; 王思文; 管怀进
22600　江苏省南通市，南通大学附属医院眼科，南通大学医学院
Author(s):
BAO Sijie; LI Pengfei; KANG Lihua; WANG Congyu; WANG Siwen; GUAN Huaijin
Department of Ophthalmology,the Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China
关键词:
RNA甲基化; m6A修饰; 眼部疾病
Keywords:
ribonucleic acid methylation;  N6-methyladenosine modification;  eye diseases
分类号:
R776
DOI:
10.13389/j.cnki.rao.2023.0081
文献标志码:
A
摘要:
N6-甲基腺苷（m6A）是指在腺嘌呤的第6个N位点上发生的甲基化修饰，修饰过程主要由甲基转移酶、去甲基化酶和识别酶共同协调完成。RNA甲基化m6A修饰不仅能够调节mRNA代谢，包括mRNA选择性剪接、核输出、翻译和稳定性，而且参与多种细胞生物学过程，比如胚胎发育、免疫调节、脂肪代谢、生物节律等，进而影响疾病的发生发展。本文就RNA甲基化m6A修饰在眼部疾病，包括眼表疾病、青光眼、白内障、视网膜疾病、葡萄膜疾病、Graves眼病和眼部肿瘤的最新进展作一综述。
Abstract:
N6-methyladenosine (m6A) refers to the methylation modification that occurs at the 6th N site of adenine, and the modification is completed by methyltransferases, demethylases and recognition enzymes. The m6A ribonucleic acid (RNA) methylation modification can regulate the messenger ribonucleic acid (mRNA) metabolism, such as alternative splicing, nuclear export, translation and stability of mRNA. Meanwhile, it can participate in various cellular biological processes, such as embryonic development, immune regulation, fat metabolism, and biological rhythms, which subsequently affect the occurrence and development of diseases. This paper was to summarize the recent research progress of m6A RNA methylation modification in eye diseases, including ocular surface diseases, glaucoma, cataracts, retinal diseases, uveal diseases, Graves eye diseases, and ocular tumors.

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备注/Memo

备注/Memo:
国家自然科学基金面上项目（编号：82171038，82101101）
更新日期/Last Update: 2023-05-05