[1]朱君雅,姚文,倪锡森,等.糖尿病性黄斑水肿的病理生理机制：神经血管单元研究现状[J].眼科新进展,2023,43(1):066-70.[doi:10.13389/j.cnki.rao.2023.0014]
　ZHU Junya,YAO Wen,NI Xinsen,et al.Pathophysiology of diabetic macular edema: current status of neurovascular unit research[J].Recent Advances in Ophthalmology,2023,43(1):066-70.[doi:10.13389/j.cnki.rao.2023.0014]
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糖尿病性黄斑水肿的病理生理机制：神经血管单元研究现状/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
43卷
期数:
2023年1期
页码:
066-70
栏目:
文献综述
出版日期:
2023-01-05

文章信息/Info

Title:
Pathophysiology of diabetic macular edema: current status of neurovascular unit research
作者:
朱君雅; 姚文; 倪锡森; 蒋沁
210029　江苏省南京市，南京医科大学（朱君雅，姚文，倪锡森，蒋沁）；210000　江苏省南京市，南京医科大学附属眼科医院（蒋沁）
Author(s):
ZHU Junya1; YAO Wen1; NI Xinsen1; JIANG Qin1; 2
1.Nanjing Medical University,Nanjing 210029,Jiangsu Province,China
2.The Affiliated Eye Hospital of Nanjing Medical University,Nanjing 210000,Jiangsu Province,China
关键词:
神经血管单元; 糖尿病黄斑水肿; 糖尿病视网膜病变
Keywords:
neurovascular unit;  diabetic macular edema;  diabetic retinopathy
分类号:
R774.1
DOI:
10.13389/j.cnki.rao.2023.0014
文献标志码:
A
摘要:
糖尿病性黄斑水肿（DME）是引起糖尿病视网膜病变患者视力损害的主要原因，其发病机制尚不明确。近年来认为DR是神经血管单元（NVU）损伤引起的一类神经血管性疾病，NVU主要由神经元、胶质细胞和血管细胞构成，神经系统和血管组织相互协同依赖。视网膜血管结构作为血-视网膜屏障的重要组成部分，其功能基于NVU中血管神经耦合形成一个精密的功能整体，能够有效维持视网膜内稳态，对维持正常视功能至关重要。本文从NVU的角度就DME的调节机制进行综述。
Abstract:
The pathophysiology of diabetic macular edema (DME), a primary contributor to visual impairment of diabetic retinopathy (DR) patients, is yet unknown. The neurovascular unit (NVU), which is primarily made up of neurons, glial cells, and vascular cells, is assumed to be the source of DR, a family of neurovascular illnesses. The neurological system and vascular tissue are mutually dependent on one another. As a crucial part of the blood-retina barrier, the vascular structure of the retina acts as a sophisticated functional whole based on the vascular-neural coupling in the NVU, which is crucial for maintaining intraretinal homeostasis and normal visual function. This article reviews the regulatory mechanisms of DME from the perspective of the NVU.

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备注/Memo

备注/Memo:
国家自然科学基金项目（编号：82070983）；江苏省研究生科研与实践创新计划项目（编号：KYCX22_1807）
更新日期/Last Update: 2023-01-05