参考文献/References:
［1］ HAKANSSON A P,ORIHUELA C J,BOGAERT D.Bacterial-host interactions:physiology and pathophysiology of respiratory infection［J］.Physiol Rev,2018,98(2):781-811.
［2］ MCFALL-NGAI M.Adaptive immunity:care for the community［J］.Nature,2007,445(7124):153.
［3］ SCHRETTER C E,MAZMANIAN S K.Cultivating a relationship with gut bacteria［J］.Cell Metab,2018,27(2):267-268.
［4］ TOKARZ-DEPTULA B,SLIWA-DOMINIAK J,ADAMIAK M,BAK K,DEPTULA W.Commensal bacteria and immunity of the gastrointestinal,respiratory and genitourinary tracts［J］.Postepy Hig Med Dosw (Online),2016,70:599-609.
［5］ IVANOV I I,HONDA K.Intestinal commensal microbes as immune modulators［J］.Cell Host Microbe,2012,12(4):496-508.
［6］ ST LEGER A J,CASPI R R.Visions of eye commensals:the known and the unknown about how the microbiome affects eye disease［J］.Bioessays,2018,40(11):e1800046.
［7］ EVANS D J,MCNAMARA N A,FLEISZIG S M.Life at the front:dissecting bacterial-host interactions at the ocular surface［J］.Ocul Surf,2007,5(3):213-227.
［8］ KUGADAS A,GADJEVA M.Impact of microbiome on ocular health［J］.Ocul Surf,2016,14(3):342-349.
［9］ NAIK S,BOULADOUX N,LINEHAN J L,HAN S J,HARRISON O J,WILHELM C,et al.Commensal-dendritic-cell interaction specifies a unique protective skin immune signature［J］.Nature,2015,520(7545):104-108.
［10］ ROBERTSON D M,CAVANAGH H D.The clinical and cellular basis of contact lens-related corneal infections:a review［J］.Clin Ophthalmol,2008,2(4):907-917.
［11］ KUGADAS A,CHRISTIANSEN S H,SANKARANARAYANAN S,SURANA N K,GAUGUET S,KUNZ R,et al.Impact of microbiota on resistance to ocular pseudomonas aeruginosa-induced keratitis［J］.PLoS Pathog,2016,12(9):e1005855.
［12］ KUGADAS A,WRIGHT Q,GEDDES-MCALISTER J,GADJEVA M.Role of microbiota in strengthening ocular mucosal barrier function through secretory IgA［J］.Invest Ophthalmol Vis Sci,2017,58(11):4593-4600.
［13］ MCDERMOTT A M.Antimicrobial compounds in tears［J］.Exp Eye Res,2013,117:53-61.
［14］ ST LEGER A J,DESAI J V,DRUMMOND R A,KUGADAS A,ALMAGHRABI F,SILVER P,et al.An ocular commensal protects against corneal infection by driving an interleukin-17 response from mucosal gammadelta T cells［J］.Immunity,2017,47(1):148-158.
［15］ ZHANG X,VOLPE E A,GANDHI N B,SCHAUMBURG C S,SIEMASKO K F,PANGELINAN S B,et al.NK cells promote Th-17 mediated corneal barrier disruption in dry eye［J］.PLoS One,2012,7(5):e36822.
［16］ JONES B W,PFEIFFER R L,FERRELL W D,WATT C B,TUCKER J,MARC R E.Retinal remodeling and metabolic alterations in human AMD［J］.Front Cell Neurosci,2016,10:103.
［17］ ROWAN S,JIANG S,KOREM T,SZYMANSKI J,CHANG M L,SZELOG J,et al.Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration［J］.Proc Natl Acad Sci U S A,2017,114(22):E4472-E4481.
［18］ ANDRIESSEN E M,WILSON A M,MAWAMBO G,DEJDA A,MILOUDI K,SENNLAUB F,et al.Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization［J］.Embo Mol Med,2016,8(12):1366-1379.
［19］ TSAI T,GROTEGUT P,REINEHR S,JOACHIM S C.Role of heat shock proteins in glaucoma［J］.Int J Mol Sci,2019,20(20)：5160.
［20］ WILLIAMS P A,MARSH-ARMSTRONG N,HOWELL G R.Neuroinflammation in glaucoma:a new opportunity［J］.Exp Eye Res,2017,157(1):20-27.
［21］ ASTAFUROV K,ELHAWY E,REN L,DONG C Q,IGBOIN C,HYMAN L,et al.Oral microbiome link to neurodegeneration in glaucoma［J］.PLoS One,2014,9(9):e104416.
［22］ HARRINGTON L E,HATTON R D,MANGAN P R,TURNER H,MURPHY T L,MURPHY K M,et al.Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages［J］.Nat Immunol,2005,6(11):1123-1132.
［23］ KAMALI A N,NOORBAKHSH S M,HAMEDIFAR H,JADIDI-NIARAGH F,YAZDANI R,BAUTISTA J M,et al.A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders［J］.Mol Immunol,2019,105:107-115.
［24］ WU H J,IVANOV I I,DARCE J,HATTORI K,SHIMA T,UMESAKI Y,et al.Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells［J］.Immunity,2010,32(6):815-827.
［25］ ZHONG Z,SU G,KIJLSTRA A,YANG P.Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis［J］.Prog Retin Eye Res,2021,80:100866.
［26］ JABS D A,NUSSENBLATT R B,ROSENBAUM J T.Standardization of uveitis nomenclature for reporting clinical data.Results of the First International Workshop［J］.Am J Ophthalmol,2005,140(3):509-516.
［27］ HORAI R,ZARATE-BLADES C R,DILLENBURG-PILLA P,CHEN J,KIELCZEWSKI J L,SILVER P B,et al.Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site［J］.Immunity,2015,43(2):343-353.
［28］ NAKAMURA Y K,METEA C,KARSTENS L,ASQUITH M,GRUNER H,MOSCIBROCKI C,et al.Gut microbial alterations associated with protection from autoimmune uveitis［J］.Invest Ophthalmol Vis Sci,2016,57(8):3747-3758.
［29］ NAKAMURA Y K,JANOWITZ C,METEA C,ASQUITH M,KARSTENS L,ROSENBAUM J T,et al.Short chain fatty acids ameliorate immune-mediated uveitis partially by altering migration of lymphocytes from the intestine［J］.Sci Rep,2017,7(1):11745.
［30］ AKKOC N,YARKAN H,KENAR G,KHAN M A.Ankylosing spondylitis:HLA-B*27-positive versus HLA-B*27-negative disease［J］.Curr Rheumatol Rep,2017,19(5):26.
［31］ TAUROG J D,RICHARDSON J A,CROFT J T,SIMMONS W A,ZHOU M,FERNANDEZ-SUEIRO J L,et al.The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats［J］.J Exp Med,1994,180(6):2359-2364.
［32］ ROSENBAUM J T,ASQUITH M.The microbiome and HLA-B27-associated acute anterior uveitis［J］.Nat Rev Rheumatol,2018,14(12):704-713.
［33］ HAPFELMEIER S,LAWSON M A,SLACK E,KIRUNDI J K,STOEL M,HEIKENWALDER M,et al.Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses［J］.Science,2010,328(5986):1705-1709.
［34］ ATARASHI K,TANOUE T,SHIMA T,IMAOKA A,KUWAHARA T,MOMOSE Y,et al.Induction of colonic regulatory T cells by indigenous clostridium species［J］.Science,2011,331(6015):337-341.
［35］ BOUSKRA D,BREZILLON C,BERARD M,WERTS C,VARONA R,BONECA I G,et al.Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis［J］.Nature,2008,456(7221):507-510.
［36］ YE Z,ZHANG N,WU C,ZHANG X,WANG Q,HUANG X,et al.A metagenomic study of the gut microbiome in Behcet’s disease［J］.Microbiome,2018,6(1):135.
［37］ YE Z,WU C,ZHANG N,DU L,CAO Q,HUANG X,et al.Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease［J］.Gut Microbes,2020，11(3):539-555.
［38］ WEINGARDEN A R,VAUGHN B P.Intestinal microbiota,fecal microbiota transplantation,and inflammatory bowel disease［J］.Gut Microbes,2017,8(3):238-252.
［39］ VAVRICKA S R,SCHOEPFER A,SCHARL M,LAKATOS P L,NAVARINI A,ROGLER G.Extraintestinal manifestations of inflammatory bowel disease［J］.Inflamm Bowel Dis,2015,21(8):1982-1992.
［40］ BRITO-ZERON P,BALDINI C,BOOTSMA H,BOWMAN S J,JONSSON R,MARIETTE X,et al.Sjogren syndrome［J］.Nat Rev Dis Primers,2016,2:16047.
［41］ WANG C,ZAHEER M,BIAN F,QUACH D,SWENNES A G,BRITTON R A,et al.Sjogren-like lacrimal keratoconjunctivitis in germ-free mice［J］.Int J Mol Sci,2018,19(2):565.
［42］ ZAHEER M,WANG C,BIAN F,YU Z,HERNANDEZ H,DE SOUZA R G,et al.Protective role of commensal bacteria in Sjogren syndrome［J］.J Autoimmun,2018,93:45-56.
［43］ DE PAIVA C S,JONES D B,STERN M E,BIAN F,MOORE Q L,CORBIERE S,et al.Altered mucosal microbiome diversity and disease severity in sjogren syndrome［J］.Sci Rep,2016,6:23561.
［44］ LI Z,GONG Y,CHEN S,LI S,ZHANG Y,ZHONG H,et al.Comparative portrayal of ocular surface microbe with and without dry eye［J］.J Microbiol,2019,57(11):1025-1032.