参考文献/References:
［1］ ZHU L,XU J,LIU Y,GONG T,LIU J,HUANG Q,et al.Prion protein is essential for diabetic retinopathy-associated neovascularization［J］.Angiogenesis,2018,21(4):767-775.
［2］ ZHANG X,WU J,WU C,BIAN A L,GENG S,DAI R P.Comparison of aqueous humor levels of PIGF and VEGF in proliferative diabetic retinopathy before and after intravitreal conbercept injection［J］.Diabetes Res Clin Pract,2020,162:108083.
［3］ HANNA R M,BARSOUM M,ARMAN F,SELAMET U,HASNAIN H,KURTZ I.Nephrotoxicity induced by intravitreal vascular endothelial growth factor inhibitors:emerging evidence［J］.Kidney Int,2019,96(3):572-580.
［4］ WUBBEN T J,JOHNSON M W,Group Treatment Interruption Study Anti-VEGF.Anti-vascular endothelial growth factor therapy for diabetic retinopathy:consequences of inadvertent treatment interruptions［J］.Am J Ophthalmol,2019,204:13-18.
［5］ DARCHE M,COSSUTTA M,CARUANA L,HOUPPE C,GILLES M E,HABERT D,et al.Antagonist of nucleolin,N6L,inhibits neovascularization in mouse models of retinopathies［J］.FASEB J,2020,34(4):5851-5862.
［6］ YIM Y Y,ZURAWSKI Z,HAMM H.GPCR regulation of secretion［J］.Pharmacol Ther,2018,192:124-140.
［7］ MNDEZ-LUNA D,MORELOS-GARNICA L A,GARCA-VZQUEZ J B,BELLO M,PADILLA-MARTNEZ I I,FRAGOSO-VZQUEZ M J,et al.Modifications on the tetrahydroquinoline scaffold targeting a phenylalanine cluster on GPER as antiproliferative compounds against renal,liver and pancreatic cancer cells［J］.Pharmaceuticals (Basel),2021,14(1):49.
［8］ ASCHNER P,KARURANGA S,JAMES S,SIMMONS D,BASIT A,SHAW J E,et al.The international diabetes federation’s guide for diabetes epidemiological studies［J］.Diabetes Res Clin Pract,2021,172:108630.
［9］ CAMPOCHIARO P A,AKHLAQ A.Sustained suppression of VEGF for treatment of retinal/choroidal vascular diseases［J］.Prog Retin Eye Res,2020,29:100921.
［10］ MAHAJAN N,ARORA P,SANDHIR R.Perturbed biochemical pathways and associated oxidative stress lead to vascular dysfunctions in diabetic retinopathy［J］.Oxid Med Cell Longev,2019,2019:8458472.
［11］ HAINSWORTH D P,BEBU I,AIELLO L P,SIVITZ W,GUBITOSI-KLUG R,MALONE J,et al.Risk factors for retinopathy in type 1 diabetes:the DCCT/EDIC study［J］.Diabetes Care,2019,42(5):875-882.
［12］ YUMNAMCHA T,GUERRA M,SINGH L P,IBRAHIM A S.Metabolic dysregulation and neurovascular dysfunction in diabetic retinopathy［J］.Antioxidants (Basel),2020,9(12):1244.
［13］ FONIN A V,DARLING A L,KUZNETSOVA I M,TUROVEROV K K,UVERSKY V N.Multi-functionality of proteins involved in GPCR and G protein signaling:making sense of structure-function continuum with intrinsic disorder-based proteoforms［J］.Cell Mol Life Sci,2019,76(22):4461-4492.
［14］ SPRANG S R.Invited review:activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis［J］.Biopolymers,2016,105(8):449-462.
［15］ OKASHAH N,WAN Q,GHOSH S,SANDHU M,INOUE A,VAIDEHI N,et al.Variable G protein determinants of GPCR coupling selectivity［J］.Proc Natl Acad Sci USA,2019,116(24):12054-12059.
［16］ YEH H Y,SUN D,YC P,WU Y L.Regulation of the regulator of G protein signaling 2 expression and cellular localization by PKA and PKC pathways in mouse granulosa cells［J］.Biochem Biophys Res Commun,2018,503(2):950-955.
［17］ SUTKEVICIUTE I,VILARDAGA J P.Structural insights into emergent signaling modes of G protein-coupled receptors［J］.J Biol Chem,2020,295(33):11626-11642.
［18］ WEINSTEIN L S.Role of G(s)α in central regulation of energy and glucose metabolism［J］.Horm Metab Res,2014,46(12):841-844.
［19］ WANG M,WANG Y,XIE T,ZHAN P,ZOU J,NIE X,et al.Prostaglandin E(2)/EP(2) receptor signalling pathway promotes diabetic retinopathy in a rat model of diabetes［J］.Diabetologia,2019,62(2):335-348.
［20］ LIU L,JIANG Y,STEINLE J J.Epac1 and glycyrrhizin both inhibit HMGB1 levels to reduce diabetes-induced neuronal and vascular damage in the mouse retina［J］.J Clin Med,2019,8(6):772.
［21］ HONASOGE A,NUDLEMAN E,SMITH M,RAJAGOPAL R.Emerging insights and interventions for diabetic retinopathy［J］.Curr Diab Rep,2019,19(10):100.
［22］ RAMOS C J,LIN C,LIU X,ANTONETTI D.The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability［J］.J Biol Chem,2018,293(2):717-730.
［23］ CAI S,YANG Q,HOU M,HAN Q,ZHANG H,WANG J,et al.Α-melanocyte-stimulating hormone protects early diabetic retina from blood-retinal barrier breakdown and vascular leakage via MC4R［J］.Cell Physiol Biochem,2018,45(2):505-522.
［24］ ZHANG Y,BO Q,WU W,XU C,YU G,MA S,et al.α-melanocyte-stimulating hormone prevents glutamate excitotoxicity in developing chicken retina via MC4r-mediated down-regulation of microRNA-194［J］.Sci Rep,2015,5:15812.
［25］ AKAGAWA M,MORI A,SAKAMOTO K,NAKAHARA T.Methylglyoxal impairs β(2)-adrenoceptor-mediated vasodilatory mechanisms in rat retinal arterioles［J］.Biol Pharm Bull,2018,41(2):272-276.
［26］ GBRIEL R,PSTYNI E,DNES V.Neuroprotective potential of pituitary adenylate cyclase activating polypeptide in retinal degenerations of metabolic origin［J］.Front Neurosci,2019,13:1031.
［27］ FABIAN E,REGLODI D,HORVATH G,OPPER B,TOTH G,FAZAKAS C,et al.Pituitary adenylate cyclase activating polypeptide acts against neovascularization in retinal pigment epithelial cells［J］.Ann N Y Acad Sci,2019,1455(1):160-172.
［28］ SANTOS-CARVALHO A,ELVAS F,ALVARO A R,AMBRSIO A F,CAVADAS C.Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate［J］.Cell Death Dis,2013,4(5):e636.
［29］ GUPTA A,JELINEK H F,AL-AUBAIDY H.Glucagon like peptide-1 and its receptor agonists:their roles in management of type 2 diabetes mellitus［J］.Diabetes Metab Syndr,2017,11(3):225-230.
［30］ DOUROS A,FILION K B,YIN H,YU O H,ETMINAN M,UDELL J A,et al.Glucagon-like peptide 1 receptor agonists and the risk of incident diabetic retinopathy［J］.Diabetes Care,2018,41(11):2330-2338.
［31］ DE OLIVEIRA P G,RAMOS M,AMARO A J,DIAS R A,VIEIRA S.G(i/o)-protein coupled receptors in the aging brain［J］.Front Aging Neurosci,2019,11:89.
［32］ KOLKO M,VOSBORG F,HENRIKSEN U L,HASAN-OLIVE M M,DIGET E H,VOHRA R,et al.Lactate transport and receptor actions in retina:potential roles in retinal function and disease［J］.Neurochem Res,2016,41(6):1229-1236.
［33］ OMORI K,NAGATA N,KURATA K,FUKUSHIMA Y,SEKIHACHI E,FUJII N,et al.Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas［J］.JCI Insight,2018,3(23):120706.
［34］ MAZZEO A,ARROBA A I,BELTRAMO E,VALVERDE A M,PORTA M.Somatostatin protects human retinal pericytes from inflammation mediated by microglia［J］.Exp Eye Res,2017,164:46-54.
［35］ SIM R,HERNNDEZ C,PORTA M,BANDELLO F,GRAUSLUND J,HARDING S P,et al.Effects of topically administered neuroprotective drugs in early stages of diabetic retinopathy:results of the EUROCONDOR clinical trial［J］.Diabetes,2019,68(2):457-463.
［36］ CHANG W,LAJKO M,FAWZI A A.Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes［J］.PLoS One,2018,13(1):e0191285.
［37］ ALRASHDI S F,DELIYANTI D,WILKINSON-BERKA J L.Intravitreal administration of endothelin type A receptor or endothelin type B receptor antagonists attenuates hypertensive and diabetic retinopathy in rats［J］.Exp Eye Res,2018,176:1-9.
［38］ ZOU Q Y,ZHAO Y J,ZHOU C,LIU A X,ZHONG X Q,YAN Q,et al.G protein α subunit 14 mediates fibroblast growth factor 2-induced cellular responses in human endothelial cells［J］.J Cell Physiol,2019,234(7):10184-10195.
［39］ LIZUNKOVA P,ENUWOSA E,CHICHGER H.Activation of the sweet taste receptor T1R3 by sucralose attenuates VEGF-induced vasculogenesis in a cell model of the retinal microvascular endothelium［J］.Graefes Arch Clin Exp Ophthalmol,2019,257(1):71-81.
［40］ PHIPPS J A,VESSEY K A,BRANDLI A,NAG N,TRAN M X,JOBLING A,et al.The role of angiotensin II/AT1 receptor signaling in regulating retinal microglial activation［J］.Invest Ophthalmol Vis Sci,2018,59(1):487-498.
［41］ HENNIG R,OHLMANN A,STAFFEL J,POLLINGER K,HAUNBERGER A,BREUNIG M,et al.Multivalent nanoparticles bind the retinal and choroidal vasculature［J］.J Control Release,2015,220(Pt A):265-274.
［42］ DU Y,CRAMER M,LEE C A,TANG J,MUTHUSAMY A,ANTONETTI D,et al.Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice:relationship to capillary degeneration and permeability［J］.FASEB J,2015,29(5):2194-2204.
［43］ KARLS A,MYNLIEFF M.GABA(B) receptors couple to Gαq to mediate increases in voltage-dependent calcium current during development［J］.J Neurochem,2015,135(1):88-100.
［44］ ELMASRY K,IBRAHIM A S,SALEH H,ELSHERBINY N,ELSHAFEY S,HUSSEIN K A,et al.Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy［J］.Diabetologia,2018,61(5):1220-1232.
［45］ HACHANA S,BHAT M,SNCAL J,HUPP-GOURGUES F,COUTURE R,VAUCHER E.Expression,distribution and function of kinin B(1) receptor in the rat diabetic retina［J］.Br J Pharmacol,2018,175(6):968-983.