[1]李雁,文小凤,魏来.非感染性葡萄膜炎343例患者的分型、临床表现及并发症[J].眼科新进展,2021,41(7):673-675.[doi:10.13389/j.cnki.rao.2021.0139]
　LI Yan,WEN Xiaofeng,WEI Lai.Classification, clinical manifestations and complications of 343 non-infectious uveitis patients[J].Recent Advances in Ophthalmology,2021,41(7):673-675.[doi:10.13389/j.cnki.rao.2021.0139]
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非感染性葡萄膜炎343例患者的分型、临床表现及并发症/HTML
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《眼科新进展》[ISSN:1003-5141/CN:41-1105/R]

卷:
41卷
期数:
2021年7期
页码:
673-675
栏目:
应用研究
出版日期:
2021-07-05

文章信息/Info

Title:
Classification, clinical manifestations and complications of 343 non-infectious uveitis patients
作者:
李雁; 文小凤; 魏来
523000　广东省东莞市，广东省东莞光明眼科医院（李雁）；510060　广东省广州市，中山大学中山眼科中心国家重点实验室（文小凤 ，魏来 ）
Author(s):
LI Yan1; WEN Xiaofeng2; WEI Lai2
1.Department of Ophthalmology, Dongguan Guangming Ophthalmic Hospital, Dongguan 523000, Guangdong Province, China
2.State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China
关键词:
非感染性葡萄膜炎; Behcet病; VKH综合征; 并发症
Keywords:
non-infectious uveitis;  Behcet’s disease;  Vogt-Koyanagi Harada syndrome;  complication
分类号:
R773
DOI:
10.13389/j.cnki.rao.2021.0139
文献标志码:
A
摘要:
目的　探讨非感染性葡萄膜炎患者的分型、临床表现及并发症。方法　选取2016年5月至2018年2月就诊于中山大学中山眼科中心葡萄膜炎专科并确诊为非感染性葡萄膜炎的患者343例（630眼）病历资料。记录入组患者一般资料，对患者进行详细的眼部检查。非感染性葡萄膜炎的诊断及分型参照2005年葡萄膜炎命名标准化工作组提出的相关标准。总结343例非感染性葡萄膜炎患者的分型、临床表现及并发症。结果　343例（630眼）非感染性葡萄膜炎患者中，56例单眼受累，287例双眼受累；男女比例为1.4∶1.0；发病年龄为21～50（36.3±12.4）岁。无明确病因的特发性患者122例，已明确病因患者221例，以Behcet病（30.3%）和VKH综合征（20.7%）最常见。343例非感染性葡萄膜炎患者按照炎症发生或累及的解剖部位分类，全葡萄膜炎（177/343，51.6%）占比最多，其他依次为中间葡萄膜炎（72/343，21.0%）、后葡萄膜炎（53/343，15.4%）、前葡萄膜炎（41/343，12.0%）。104例Behcet病性葡萄膜炎患者中出现复发性口腔溃疡91例、结节性红斑37例。71例VKH综合征性葡萄膜炎患者出现耳鸣39例、皮肤及毛发异常11例、头皮痛或感觉异常9例。343例非感染性葡萄膜炎患者眼部并发症以白内障（228例）最为常见，其次分别是视神经萎缩（39例）、黄斑萎缩（38例）和继发性青光眼（36例）。结论　非感染性葡萄膜炎患者中，全葡萄膜炎的发生率高于前葡萄膜炎；Behcet病性葡萄膜炎和VKH综合征性葡萄膜炎仍是我国最常见的全葡萄膜炎类型。
Abstract:
Objective　To investigate and analyze the classification, clinical manifestations and complications of non-infectious uveitis.Methods　The medical records of 343 patients (630 eyes) who were diagnosed with non-infectious uveitis in the uveitis specialist of Zhongshan Ophthalmology Center of Sun Yat-sen University from May 2016 to February 2018 were selected. General information of the enrolled patients was recorded, and detailed eye examinations were performed. The diagnosis and classification of non-infectious uveitis were based on the criteria proposed by the Uveitis Nomenclature Standardization Working Group in 2005, followed by summarizing the classification, clinical manifestations and complications of these patients.Results　Of 343 patients (630 eyes) with noninfectious uveitis, 56 patients were involved in one eye and 287 patients in both eyes. The male to female ratio was 1.4∶1.0. The onset age was 21~50 (36.3±12.4) years. There were 122 idiopathic patients without clear etiology. Among 221 patients with clear etiology, and Behcet’s disease (30.3%) and Vogt-Koyanagi Harada(VKH) syndrome (20.7%) were the most common diseases. A total of 343 patients with non-infectious uveitis were classified according to the anatomical sites where inflammation occurred or was involved. Panuveitis (177/343, 51.6%) was the most common, followed by intermediate uveitis (72/343, 21.0%), posterior uveitis (53/343, 15.4%), and anterior uveitis (41/343, 12.0%). Among 104 uveitis patients with Behcet’s disease, 91 patients had recurrent oral ulcer and 37 patients had erythema nodosum. In 71 uveitis patients with VKH syndrome, tinnitus occurred in 39 patients, skin and hair abnormalities in 11 patients, and scalp pain or paresthesia in 9 patients. Among the 343 non-infectious uveitis patients, cataract (228 patients) is the most common ocular complication, followed by optic nerve atrophy (39 patients), macular atrophy (38 patients), and secondary glaucoma (36 patients).Conclusion　The incidence of panuveitis is higher than anterior uveitis. Behcet’s disease and VKH syndrome are still the most common types of panuveitis in China.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2021-07-05